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Restoration of renal TIMP3 levels via genetics and pharmacological approach prevents experimental diabetic nephropathy

BACKGROUND: Diabetic nephropathy (DN), one of the major complications of diabetes, is characterized by albuminuria, glomerulosclerosis, and progressive loss of renal function. Loss of TIMP3, an Extracellular Matrix bound protein affecting both inflammation and fibrosis, is a hallmark of DN in human...

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Detalles Bibliográficos
Autores principales:	Casagrande, Viviana, Iuliani, Giulia, Menini, Stefano, Pugliese, Giuseppe, Federici, Massimo, Menghini, Rossella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862169/ https://www.ncbi.nlm.nih.gov/pubmed/33634991 http://dx.doi.org/10.1002/ctm2.305

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