Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma

High-grade glioma is the most common and aggressive primary brain tumor in adults with poor therapeutic efficiency and survival prognosis. Cell division cycle associated 8 (CDCA8) has been well known as a cell cycle regulator and tumor promotor in various malignant tumors. However, its biological ro...

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Autores principales: Wang, Xiaoxiong, Wang, Heping, Xu, Jiajun, Hou, Xu, Zhan, Haoqiang, Zhen, Yunbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862266/
https://www.ncbi.nlm.nih.gov/pubmed/33542211
http://dx.doi.org/10.1038/s41419-021-03405-4
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author Wang, Xiaoxiong
Wang, Heping
Xu, Jiajun
Hou, Xu
Zhan, Haoqiang
Zhen, Yunbo
author_facet Wang, Xiaoxiong
Wang, Heping
Xu, Jiajun
Hou, Xu
Zhan, Haoqiang
Zhen, Yunbo
author_sort Wang, Xiaoxiong
collection PubMed
description High-grade glioma is the most common and aggressive primary brain tumor in adults with poor therapeutic efficiency and survival prognosis. Cell division cycle associated 8 (CDCA8) has been well known as a cell cycle regulator and tumor promotor in various malignant tumors. However, its biological role in glioma still remains unclear. Our results showed that high level of CDCA8 was significantly correlated with advanced WHO grade and poor overall survival and disease-free survival prognosis. In vitro and in vivo investigations demonstrated that CDCA8 promoted the glioma malignancy by promoting cell proliferation, cell migration, and inhibiting cell apoptosis. Moreover, we found its synergetic biological protein—E2F1 by the gene microarray chip. In this study, we revealed that CDCA8 synergized with E2F1 facilitated the proliferation and migration of glioma. In conclusion, our study provides a novel promising therapeutic targets and prognostic biomarkers for malignant glioma treatment.
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spelling pubmed-78622662021-02-11 Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma Wang, Xiaoxiong Wang, Heping Xu, Jiajun Hou, Xu Zhan, Haoqiang Zhen, Yunbo Cell Death Dis Article High-grade glioma is the most common and aggressive primary brain tumor in adults with poor therapeutic efficiency and survival prognosis. Cell division cycle associated 8 (CDCA8) has been well known as a cell cycle regulator and tumor promotor in various malignant tumors. However, its biological role in glioma still remains unclear. Our results showed that high level of CDCA8 was significantly correlated with advanced WHO grade and poor overall survival and disease-free survival prognosis. In vitro and in vivo investigations demonstrated that CDCA8 promoted the glioma malignancy by promoting cell proliferation, cell migration, and inhibiting cell apoptosis. Moreover, we found its synergetic biological protein—E2F1 by the gene microarray chip. In this study, we revealed that CDCA8 synergized with E2F1 facilitated the proliferation and migration of glioma. In conclusion, our study provides a novel promising therapeutic targets and prognostic biomarkers for malignant glioma treatment. Nature Publishing Group UK 2021-02-01 /pmc/articles/PMC7862266/ /pubmed/33542211 http://dx.doi.org/10.1038/s41419-021-03405-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Xiaoxiong
Wang, Heping
Xu, Jiajun
Hou, Xu
Zhan, Haoqiang
Zhen, Yunbo
Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title_full Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title_fullStr Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title_full_unstemmed Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title_short Double-targeting CDCA8 and E2F1 inhibits the growth and migration of malignant glioma
title_sort double-targeting cdca8 and e2f1 inhibits the growth and migration of malignant glioma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862266/
https://www.ncbi.nlm.nih.gov/pubmed/33542211
http://dx.doi.org/10.1038/s41419-021-03405-4
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