Mutated clones driving leukemic transformation are already detectable at the single-cell level in CD34-positive cells in the chronic phase of primary myelofibrosis

Disease progression of myeloproliferative neoplasms is the result of increased genomic complexity. Since the ability to predict disease evolution is crucial for clinical decisions, we studied single-cell genomics and transcriptomics of CD34-positive cells from a primary myelofibrosis (PMF) patient w...

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Detalles Bibliográficos
Autores principales: Parenti, Sandra, Rontauroli, Sebastiano, Carretta, Chiara, Mallia, Selene, Genovese, Elena, Chiereghin, Chiara, Peano, Clelia, Tavernari, Lara, Bianchi, Elisa, Fantini, Sebastian, Sartini, Stefano, Romano, Oriana, Bicciato, Silvio, Tagliafico, Enrico, Della Porta, Matteo, Manfredini, Rossella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862275/
https://www.ncbi.nlm.nih.gov/pubmed/33542466
http://dx.doi.org/10.1038/s41698-021-00144-9

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