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The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases

RNA polymerases (RNAPs) synthesize RNA from NTPs, whereas DNA polymerases synthesize DNA from 2′dNTPs. DNA polymerases select against NTPs by using steric gates to exclude the 2′OH, but RNAPs have to employ alternative selection strategies. In single-subunit RNAPs, a conserved Tyr residue discrimina...

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Detalles Bibliográficos
Autores principales:	Mäkinen, Janne J., Shin, Yeonoh, Vieras, Eeva, Virta, Pasi, Metsä-Ketelä, Mikko, Murakami, Katsuhiko S., Belogurov, Georgiy A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862312/ https://www.ncbi.nlm.nih.gov/pubmed/33542236 http://dx.doi.org/10.1038/s41467-021-21005-w

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