Cargando…

Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice

Alzheimer’s disease (AD), a neurodegenerative disorder marked by accumulation of extracellular amyloid-β (Aβ) plaques leads to progressive loss of memory and cognitive function. Resting-state fMRI (RS-fMRI) studies have provided links between these two observations in terms of disruption of default...

Descripción completa

Detalles Bibliográficos
Autores principales: Adhikari, Mohit H., Belloy, Michaël E., Van der Linden, Annemie, Keliris, Georgios A., Verhoye, Marleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862346/
https://www.ncbi.nlm.nih.gov/pubmed/33551755
http://dx.doi.org/10.3389/fncir.2020.612529
_version_ 1783647270718144512
author Adhikari, Mohit H.
Belloy, Michaël E.
Van der Linden, Annemie
Keliris, Georgios A.
Verhoye, Marleen
author_facet Adhikari, Mohit H.
Belloy, Michaël E.
Van der Linden, Annemie
Keliris, Georgios A.
Verhoye, Marleen
author_sort Adhikari, Mohit H.
collection PubMed
description Alzheimer’s disease (AD), a neurodegenerative disorder marked by accumulation of extracellular amyloid-β (Aβ) plaques leads to progressive loss of memory and cognitive function. Resting-state fMRI (RS-fMRI) studies have provided links between these two observations in terms of disruption of default mode and task-positive resting-state networks (RSNs). Important insights underlying these disruptions were recently obtained by investigating dynamic fluctuations in RS-fMRI signals in old TG2576 mice (a mouse model of amyloidosis) using a set of quasi-periodic patterns (QPP). QPPs represent repeating spatiotemporal patterns of neural activity of predefined temporal length. In this article, we used an alternative methodology of co-activation patterns (CAPs) that represent instantaneous and transient brain configurations that are likely contributors to the emergence of commonly observed RSNs and QPPs. We followed a recently published approach for obtaining CAPs that divided all time frames, instead of those corresponding to supra-threshold activations of a seed region as done traditionally, to extract CAPs from RS-fMRI recordings in 10 TG2576 female mice and eight wild type littermates at 18 months of age. Subsequently, we matched the CAPs from the two groups using the Hungarian method and compared the temporal (duration, occurrence rate) and the spatial (lateralization of significantly co-activated and co-deactivated voxels) properties of matched CAPs. We found robust differences in the spatial components of matched CAPs. Finally, we used supervised learning to train a classifier using either the temporal or the spatial component of CAPs to distinguish the transgenic mice from the WT. We found that while duration and occurrence rates of all CAPs performed the classification with significantly higher accuracy than the chance-level, blood oxygen level-dependent (BOLD) signals of significantly activated voxels from individual CAPs turned out to be a significantly better predictive feature demonstrating a near-perfect classification accuracy. Our results demonstrate resting-state co-activation patterns are a promising candidate in the development of a diagnostic, and potentially, prognostic RS-fMRI biomarker of AD.
format Online
Article
Text
id pubmed-7862346
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-78623462021-02-06 Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice Adhikari, Mohit H. Belloy, Michaël E. Van der Linden, Annemie Keliris, Georgios A. Verhoye, Marleen Front Neural Circuits Neuroscience Alzheimer’s disease (AD), a neurodegenerative disorder marked by accumulation of extracellular amyloid-β (Aβ) plaques leads to progressive loss of memory and cognitive function. Resting-state fMRI (RS-fMRI) studies have provided links between these two observations in terms of disruption of default mode and task-positive resting-state networks (RSNs). Important insights underlying these disruptions were recently obtained by investigating dynamic fluctuations in RS-fMRI signals in old TG2576 mice (a mouse model of amyloidosis) using a set of quasi-periodic patterns (QPP). QPPs represent repeating spatiotemporal patterns of neural activity of predefined temporal length. In this article, we used an alternative methodology of co-activation patterns (CAPs) that represent instantaneous and transient brain configurations that are likely contributors to the emergence of commonly observed RSNs and QPPs. We followed a recently published approach for obtaining CAPs that divided all time frames, instead of those corresponding to supra-threshold activations of a seed region as done traditionally, to extract CAPs from RS-fMRI recordings in 10 TG2576 female mice and eight wild type littermates at 18 months of age. Subsequently, we matched the CAPs from the two groups using the Hungarian method and compared the temporal (duration, occurrence rate) and the spatial (lateralization of significantly co-activated and co-deactivated voxels) properties of matched CAPs. We found robust differences in the spatial components of matched CAPs. Finally, we used supervised learning to train a classifier using either the temporal or the spatial component of CAPs to distinguish the transgenic mice from the WT. We found that while duration and occurrence rates of all CAPs performed the classification with significantly higher accuracy than the chance-level, blood oxygen level-dependent (BOLD) signals of significantly activated voxels from individual CAPs turned out to be a significantly better predictive feature demonstrating a near-perfect classification accuracy. Our results demonstrate resting-state co-activation patterns are a promising candidate in the development of a diagnostic, and potentially, prognostic RS-fMRI biomarker of AD. Frontiers Media S.A. 2021-01-22 /pmc/articles/PMC7862346/ /pubmed/33551755 http://dx.doi.org/10.3389/fncir.2020.612529 Text en Copyright © 2021 Adhikari, Belloy, Van der Linden, Keliris and Verhoye. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Adhikari, Mohit H.
Belloy, Michaël E.
Van der Linden, Annemie
Keliris, Georgios A.
Verhoye, Marleen
Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title_full Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title_fullStr Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title_full_unstemmed Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title_short Resting-State Co-activation Patterns as Promising Candidates for Prediction of Alzheimer’s Disease in Aged Mice
title_sort resting-state co-activation patterns as promising candidates for prediction of alzheimer’s disease in aged mice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862346/
https://www.ncbi.nlm.nih.gov/pubmed/33551755
http://dx.doi.org/10.3389/fncir.2020.612529
work_keys_str_mv AT adhikarimohith restingstatecoactivationpatternsaspromisingcandidatesforpredictionofalzheimersdiseaseinagedmice
AT belloymichaele restingstatecoactivationpatternsaspromisingcandidatesforpredictionofalzheimersdiseaseinagedmice
AT vanderlindenannemie restingstatecoactivationpatternsaspromisingcandidatesforpredictionofalzheimersdiseaseinagedmice
AT kelirisgeorgiosa restingstatecoactivationpatternsaspromisingcandidatesforpredictionofalzheimersdiseaseinagedmice
AT verhoyemarleen restingstatecoactivationpatternsaspromisingcandidatesforpredictionofalzheimersdiseaseinagedmice