Cargando…
Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children
Repetitive hypoxia seen in obstructive sleep apnoea syndrome (OSAS) may affect bone metabolism increasing the risk for secondary osteoporosis. This study investigates the association between OSAS in children and secondary osteoporosis. This cross-sectional study included 150 children aged 10–17 year...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862364/ https://www.ncbi.nlm.nih.gov/pubmed/33542317 http://dx.doi.org/10.1038/s41598-021-82605-6 |
_version_ | 1783647274963828736 |
---|---|
author | Sies, Nur Syazwin Zaini, Azriyanti Anuar de Bruyne, Jessie Anne Jalaludin, Muhammad Yazid Nathan, Anna Marie Han, Ng Yit Thavagnanam, Surendran |
author_facet | Sies, Nur Syazwin Zaini, Azriyanti Anuar de Bruyne, Jessie Anne Jalaludin, Muhammad Yazid Nathan, Anna Marie Han, Ng Yit Thavagnanam, Surendran |
author_sort | Sies, Nur Syazwin |
collection | PubMed |
description | Repetitive hypoxia seen in obstructive sleep apnoea syndrome (OSAS) may affect bone metabolism increasing the risk for secondary osteoporosis. This study investigates the association between OSAS in children and secondary osteoporosis. This cross-sectional study included 150 children aged 10–17 years: 86 with OSAS and 64 with no OSAS. OSAS was confirmed by polysomnography. Quantitative ultrasound (QUS) of calcaneum measuring speed of sound (SoS) and broadband ultrasound attenuation (BUA) were collected. Other parameters collected including bone profile, vitamin D levels, physical activity scoring and dietary calcium intake. Majority were male and Malay ethnicity. OSAS children were mostly obese (84%) and 57% had moderate to severe OSAS. Most had lower physical activities scores. Mean (SD) phosphate and Alkaline phosphatase were lower in OSA children compared to controls: PO(4), p = 0.039 and ALP, p < 0.001. Using both single and multivariate analysis, children with OSAS had a lower mean SoS value, p < 0.001 and p = 0.004 respectively after adjusting for age, BMI and bone profile. Children with OSAS had lower SoS suggesting risk for secondary osteoporosis. QUS calcaneus is a non-invasive, feasible tool and can be used to screen risk of osteoporosis in children. Further bone mineral density assessment is needed in these groups of children to confirm diagnosis of osteoporosis. |
format | Online Article Text |
id | pubmed-7862364 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78623642021-02-05 Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children Sies, Nur Syazwin Zaini, Azriyanti Anuar de Bruyne, Jessie Anne Jalaludin, Muhammad Yazid Nathan, Anna Marie Han, Ng Yit Thavagnanam, Surendran Sci Rep Article Repetitive hypoxia seen in obstructive sleep apnoea syndrome (OSAS) may affect bone metabolism increasing the risk for secondary osteoporosis. This study investigates the association between OSAS in children and secondary osteoporosis. This cross-sectional study included 150 children aged 10–17 years: 86 with OSAS and 64 with no OSAS. OSAS was confirmed by polysomnography. Quantitative ultrasound (QUS) of calcaneum measuring speed of sound (SoS) and broadband ultrasound attenuation (BUA) were collected. Other parameters collected including bone profile, vitamin D levels, physical activity scoring and dietary calcium intake. Majority were male and Malay ethnicity. OSAS children were mostly obese (84%) and 57% had moderate to severe OSAS. Most had lower physical activities scores. Mean (SD) phosphate and Alkaline phosphatase were lower in OSA children compared to controls: PO(4), p = 0.039 and ALP, p < 0.001. Using both single and multivariate analysis, children with OSAS had a lower mean SoS value, p < 0.001 and p = 0.004 respectively after adjusting for age, BMI and bone profile. Children with OSAS had lower SoS suggesting risk for secondary osteoporosis. QUS calcaneus is a non-invasive, feasible tool and can be used to screen risk of osteoporosis in children. Further bone mineral density assessment is needed in these groups of children to confirm diagnosis of osteoporosis. Nature Publishing Group UK 2021-02-04 /pmc/articles/PMC7862364/ /pubmed/33542317 http://dx.doi.org/10.1038/s41598-021-82605-6 Text en © Crown 2021 https://creativecommons.org/licenses/by/4.0/ Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Sies, Nur Syazwin Zaini, Azriyanti Anuar de Bruyne, Jessie Anne Jalaludin, Muhammad Yazid Nathan, Anna Marie Han, Ng Yit Thavagnanam, Surendran Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title | Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title_full | Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title_fullStr | Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title_full_unstemmed | Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title_short | Obstructive sleep apnoea syndrome (OSAS) as a risk factor for secondary osteoporosis in children |
title_sort | obstructive sleep apnoea syndrome (osas) as a risk factor for secondary osteoporosis in children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862364/ https://www.ncbi.nlm.nih.gov/pubmed/33542317 http://dx.doi.org/10.1038/s41598-021-82605-6 |
work_keys_str_mv | AT siesnursyazwin obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT zainiazriyantianuar obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT debruynejessieanne obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT jalaludinmuhammadyazid obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT nathanannamarie obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT hanngyit obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren AT thavagnanamsurendran obstructivesleepapnoeasyndromeosasasariskfactorforsecondaryosteoporosisinchildren |