Cargando…

Ratio of the interferon-γ signature to the immunosuppression signature predicts anti-PD-1 therapy response in melanoma

Immune checkpoint inhibitor (ICI) treatments produce clinical benefit in many patients. However, better pretreatment predictive biomarkers for ICI are still needed to help match individual patients to the treatment most likely to be of benefit. Existing gene expression profiling (GEP)-based biomarke...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cui, Chuanliang, Xu, Canqiang, Yang, Wenxian, Chi, Zhihong, Sheng, Xinan, Si, Lu, Xie, Yihong, Yu, Jinyu, Wang, Shun, Yu, Rongshan, Guo, Jun, Kong, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862369/ https://www.ncbi.nlm.nih.gov/pubmed/33542239 http://dx.doi.org/10.1038/s41525-021-00169-w

Ejemplares similares

A machine learning framework to determine geolocations from metagenomic profiling
por: Huang, Lihong, et al.
Publicado: (2020)

Inconsistent prediction capability of ImmuneCells.Sig across different RNA-seq datasets
por: Xiao, Xu, et al.
Publicado: (2021)

Using deep learning to predict anti-PD-1 response in melanoma and lung cancer patients from histopathology images
por: Hu, Jing, et al.
Publicado: (2020)

TERT copy gain predicts the outcome of high-dose interferon α-2b therapy in acral melanoma
por: Yu, Sifan, et al.
Publicado: (2018)

Increased AURKA Gene Copy Number Correlates with Poor Prognosis and Predicts the Efficacy of High-dose Interferon Therapy in Acral Melanoma
por: Yan, Junya, et al.
Publicado: (2018)

Chemotherapy combined with antiangiogenic drugs as salvage therapy in advanced melanoma patients progressing on PD-1 immunotherapy
por: Wang, Xuan, et al.
Publicado: (2020)

Clinical presentation, histology, and prognoses of malignant melanoma in ethnic Chinese: A study of 522 consecutive cases
por: Chi, Zhihong, et al.
Publicado: (2011)

Systemic Immune-Inflammation Index and Circulating T-Cell Immune Index Predict Outcomes in High-Risk Acral Melanoma Patients Treated with High-Dose Interferon
por: Yu, Jiayi, et al.
Publicado: (2017)

The Impact of Liver Metastasis on Anti-PD-1 Monoclonal Antibody Monotherapy in Advanced Melanoma: Analysis of Five Clinical Studies
por: Wang, Xuan, et al.
Publicado: (2020)

Interferon and Biologic Signatures in Dermatomyositis Skin: Specificity and Heterogeneity across Diseases
por: Wong, David, et al.
Publicado: (2012)

Multiplexed imaging mass cytometry reveals distinct tumor-immune microenvironments linked to immunotherapy responses in melanoma
por: Xiao, Xu, et al.
Publicado: (2022)

Association of NRAS Mutation With Clinical Outcomes of Anti-PD-1 Monotherapy in Advanced Melanoma: A Pooled Analysis of Four Asian Clinical Trials
por: Zhou, Li, et al.
Publicado: (2021)

Development of an IFNγ response‐related signature for predicting the survival of cutaneous melanoma
por: Hu, Baohui, et al.
Publicado: (2020)

Potential Mutations in Uveal Melanoma Identified Using Targeted Next-Generation Sequencing
por: Yu, Jiayi, et al.
Publicado: (2019)

Performance evaluation of lossy quality compression algorithms for RNA-seq data
por: Yu, Rongshan, et al.
Publicado: (2020)

IFN-γ signature enables selection of neoadjuvant treatment in patients with stage III melanoma
por: Reijers, Irene L.M., et al.
Publicado: (2023)

Identification of immunosuppressive signature subtypes and prognostic risk signatures in triple-negative breast cancer
por: Ding, Ran, et al.
Publicado: (2023)

Molecular underpinnings of exceptional response in primary malignant melanoma of the esophagus to anti-PD-1 monotherapy
por: Dai, Jie, et al.
Publicado: (2023)

Intrahepatic transcriptomics reveals gene signatures in chronic hepatitis B patients responded to interferon therapy
por: Li, Ning, et al.
Publicado: (2022)

Safety and clinical activity with an anti-PD-1 antibody JS001 in advanced melanoma or urologic cancer patients
por: Tang, Bixia, et al.
Publicado: (2019)

Mutations in BRAF codons 594 and 596 predict good prognosis in melanoma
por: Wu, Xiaowen, et al.
Publicado: (2017)

Enhanced Immunosuppressive Properties of Human Mesenchymal Stem Cells Primed by Interferon-γ
por: Kim, Dae Seong, et al.
Publicado: (2018)

Cytokine signatures of human whole blood for monitoring immunosuppression
por: He, Yi, et al.
Publicado: (2014)

Identification of 15 lncRNAs Signature for Predicting Survival Benefit of Advanced Melanoma Patients Treated with Anti-PD-1 Monotherapy
por: Zhou, Jian-Guo, et al.
Publicado: (2021)

Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma
por: Dai, Jie, et al.
Publicado: (2017)

Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction
por: Teles, Rosane M. B., et al.
Publicado: (2019)

Animal Models of Interferon Signature Positive Lupus
por: Zhuang, Haoyang, et al.
Publicado: (2015)

Impaired interferon signature in severe COVID-19
por: Gruber, Conor
Publicado: (2020)

Uncoupling interferons and the interferon signature explain clinical and transcriptional subsets in SLE
por: Gómez-Bañuelos, Eduardo, et al.
Publicado: (2023)

Calcium-Related Gene Signatures May Predict Prognosis and Level of Immunosuppression in Gliomas
por: Liu, Peidong, et al.
Publicado: (2022)

Primary malignant melanoma of the esophagus: A retrospective analysis of clinical features, management, and survival of 76 patients
por: Wang, Xuan, et al.
Publicado: (2019)

Anti-GD2/4-1BB chimeric antigen receptor T cell therapy for the treatment of Chinese melanoma patients
por: Yu, Jiayi, et al.
Publicado: (2018)

High G2 and S‐phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis
por: Xu, Tianxiao, et al.
Publicado: (2018)

Interferon-γ induces immunosuppression in salivary adenoid cystic carcinoma by regulating programmed death ligand 1 secretion
por: Fu, Qiuyun, et al.
Publicado: (2022)

Risk Models for Advanced Melanoma Patients Under Anti-PD-1 Monotherapy—Ad hoc Analyses of Pooled Data From Two Clinical Trials
por: Bai, Xue, et al.
Publicado: (2021)

Interferon and Granulopoiesis Signatures in Systemic Lupus Erythematosus Blood
por: Bennett, Lynda, et al.
Publicado: (2003)

Gene Signatures Predict Interferon Response for MS Patients
Publicado: (2005)

An Interferon Signature Discriminates Pneumococcal From Staphylococcal Pneumonia
por: Strehlitz, Anja, et al.
Publicado: (2018)

Distinct interferon signatures stratify inflammatory and dysimmune myopathies
por: Rigolet, Muriel, et al.
Publicado: (2019)

Inflammatory bowel disease pathobiology: the role of the interferon signature
por: Andreou, Nicolaos-Panagiotis, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_mf5o7lmcgsjkfg70936m7fvvqa