A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3

Polyglutamine (polyQ) diseases comprise Huntington’s disease and several subtypes of spinocerebellar ataxia, including spinocerebellar ataxia type 3 (SCA3). The genomic expansion of coding CAG trinucleotide sequence in disease genes leads to the production and accumulation of misfolded polyQ domain-...

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Detalles Bibliográficos
Autores principales: Chen, Zhefan Stephen, Huang, Xiaoying, Talbot, Kevin, Chan, Ho Yin Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862454/
https://www.ncbi.nlm.nih.gov/pubmed/33542212
http://dx.doi.org/10.1038/s41419-021-03444-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862454/
https://www.ncbi.nlm.nih.gov/pubmed/33542212
http://dx.doi.org/10.1038/s41419-021-03444-x

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