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Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study
Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862459/ https://www.ncbi.nlm.nih.gov/pubmed/33542408 http://dx.doi.org/10.1038/s41598-021-82712-4 |
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author | Seral-Cortes, Miguel Sabroso-Lasa, Sergio De Miguel-Etayo, Pilar Gonzalez-Gross, Marcela Gesteiro, Eva Molina-Hidalgo, Cristina De Henauw, Stefaan Gottrand, Frederic Mavrogianni, Christina Manios, Yannis Plada, Maria Widhalm, Kurt Kafatos, Anthony Erhardt, Éva Meirhaeghe, Aline Salazar-Tortosa, Diego Ruiz, Jonatan Moreno, Luis A. Esteban, Luis Mariano Labayen, Idoia |
author_facet | Seral-Cortes, Miguel Sabroso-Lasa, Sergio De Miguel-Etayo, Pilar Gonzalez-Gross, Marcela Gesteiro, Eva Molina-Hidalgo, Cristina De Henauw, Stefaan Gottrand, Frederic Mavrogianni, Christina Manios, Yannis Plada, Maria Widhalm, Kurt Kafatos, Anthony Erhardt, Éva Meirhaeghe, Aline Salazar-Tortosa, Diego Ruiz, Jonatan Moreno, Luis A. Esteban, Luis Mariano Labayen, Idoia |
author_sort | Seral-Cortes, Miguel |
collection | PubMed |
description | Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents. |
format | Online Article Text |
id | pubmed-7862459 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78624592021-02-08 Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study Seral-Cortes, Miguel Sabroso-Lasa, Sergio De Miguel-Etayo, Pilar Gonzalez-Gross, Marcela Gesteiro, Eva Molina-Hidalgo, Cristina De Henauw, Stefaan Gottrand, Frederic Mavrogianni, Christina Manios, Yannis Plada, Maria Widhalm, Kurt Kafatos, Anthony Erhardt, Éva Meirhaeghe, Aline Salazar-Tortosa, Diego Ruiz, Jonatan Moreno, Luis A. Esteban, Luis Mariano Labayen, Idoia Sci Rep Article Obesity is the result of interactions between genes and environmental factors. Since monogenic etiology is only known in some obesity-related genes, a genetic risk score (GRS) could be useful to determine the genetic predisposition to obesity. Therefore, the aim of our study was to build a GRS able to predict genetic predisposition to overweight and obesity in European adolescents. A total of 1069 adolescents (51.3% female), aged 11–19 years participating in the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were genotyped. The sample was divided in non-overweight (non-OW) and overweight/obesity (OW/OB). From 611 single nucleotide polymorphisms (SNP) available, a first screening of 104 SNPs univariately associated with obesity (p < 0.20) was established selecting 21 significant SNPs (p < 0.05) in the multivariate model. Unweighted GRS (uGRS) was calculated by summing the number of risk alleles and weighted GRS (wGRS) by multiplying the risk alleles to each estimated coefficient. The area under curve (AUC) was calculated in uGRS (0.723) and wGRS (0.734) using tenfold internal cross-validation. Both uGRS and wGRS were significantly associated with body mass index (BMI) (p < .001). Both GRSs could potentially be considered as useful genetic tools to evaluate individual’s predisposition to overweight/obesity in European adolescents. Nature Publishing Group UK 2021-02-04 /pmc/articles/PMC7862459/ /pubmed/33542408 http://dx.doi.org/10.1038/s41598-021-82712-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Seral-Cortes, Miguel Sabroso-Lasa, Sergio De Miguel-Etayo, Pilar Gonzalez-Gross, Marcela Gesteiro, Eva Molina-Hidalgo, Cristina De Henauw, Stefaan Gottrand, Frederic Mavrogianni, Christina Manios, Yannis Plada, Maria Widhalm, Kurt Kafatos, Anthony Erhardt, Éva Meirhaeghe, Aline Salazar-Tortosa, Diego Ruiz, Jonatan Moreno, Luis A. Esteban, Luis Mariano Labayen, Idoia Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title | Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title_full | Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title_fullStr | Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title_full_unstemmed | Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title_short | Development of a Genetic Risk Score to predict the risk of overweight and obesity in European adolescents from the HELENA study |
title_sort | development of a genetic risk score to predict the risk of overweight and obesity in european adolescents from the helena study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862459/ https://www.ncbi.nlm.nih.gov/pubmed/33542408 http://dx.doi.org/10.1038/s41598-021-82712-4 |
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