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Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation
Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis due to limited therapeutic options. This study examines the roles of genome-wide association study identified PDAC-associated genes as therapeutic targets. We have identified HNF4G gene whose silencing most effectively repressed PDAC cell in...
Autores principales: | Wang, Chengcheng, Zhang, Taiping, Liao, Quan, Dai, Menghua, Guo, Junchao, Yang, Xinyu, Tan, Wen, Lin, Dongxin, Wu, Chen, Zhao, Yupei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Higher Education Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862466/ https://www.ncbi.nlm.nih.gov/pubmed/32737864 http://dx.doi.org/10.1007/s13238-020-00760-4 |
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