Hsp90-stabilized MIF supports tumor progression via macrophage recruitment and angiogenesis in colorectal cancer

Macrophage migration inhibitory factor (MIF) is an upstream regulator of innate immunity, but its expression is increased in some cancers via stabilization with HSP90-associated chaperones. Here, we show that MIF stabilization is tumor-specific in an acute colitis-associated colorectal cancer (CRC)...

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Detalles Bibliográficos
Autores principales: Klemke, Luisa, De Oliveira, Tiago, Witt, Daria, Winkler, Nadine, Bohnenberger, Hanibal, Bucala, Richard, Conradi, Lena-Christin, Schulz-Heddergott, Ramona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862487/
https://www.ncbi.nlm.nih.gov/pubmed/33542244
http://dx.doi.org/10.1038/s41419-021-03426-z

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