Adrenomedullin for steroid-resistant ulcerative colitis: a randomized, double-blind, placebo-controlled phase-2a clinical trial

BACKGROUND: Adrenomedullin (AM) is a bioactive peptide having many pleiotropic effects, including mucosal healing and immunomodulation. AM has shown beneficial effects in rodent models and in preliminary study for patients with ulcerative colitis (UC). We performed a clinical trial to investigate th...

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Detalles Bibliográficos
Autores principales: Kita, Toshihiro, Ashizuka, Sinya, Ohmiya, Naoki, Yamamoto, Takayuki, Kanai, Takanori, Motoya, Satoshi, Hirai, Fumihito, Nakase, Hiroshi, Moriyama, Tomohiko, Nakamura, Masanao, Suzuki, Yasuo, Kanmura, Shuji, Kobayashi, Taku, Ohi, Hidehisa, Nozaki, Ryoichi, Mitsuyama, Keiichi, Yamamoto, Shojiro, Inatsu, Haruhiko, Watanabe, Koji, Hibi, Toshifumi, Kitamura, Kazuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Original Article—Alimentary Tract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862507/
https://www.ncbi.nlm.nih.gov/pubmed/33140199
http://dx.doi.org/10.1007/s00535-020-01741-4

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