Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2

The type II transmembrane serine protease TMPRSS2 facilitates the entry of coronaviruses, such as SARS-CoV-2, into host cells by cleaving the S(1)/S(2) interface of the viral spike protein. Based on structural data derived from X-ray crystallographic data of related trypsin-like proteases, a homolog...

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Detalles Bibliográficos
Autores principales: Escalante, Diego E., Ferguson, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862521/
https://www.ncbi.nlm.nih.gov/pubmed/33564221
http://dx.doi.org/10.1007/s00044-021-02708-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862521/
https://www.ncbi.nlm.nih.gov/pubmed/33564221
http://dx.doi.org/10.1007/s00044-021-02708-7

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