The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo

Scrapie prion, PrP(Sc), formation is the central event of all types of transmissible spongiform encephalopathies (TSEs), while the pathway with possible intermediates and their mechanism of formation from the normal isoform of prion (PrP), remains not fully understood. Recently, the G127V variant of...

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Detalles Bibliográficos
Autores principales: Sangeetham, Sudheer Babu, Engelke, Anna Dorothee, Fodor, Elfrieda, Krausz, Sarah Laura, Tatzelt, Jörg, Welker, Ervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862613/
https://www.ncbi.nlm.nih.gov/pubmed/33542378
http://dx.doi.org/10.1038/s41598-021-82647-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862613/
https://www.ncbi.nlm.nih.gov/pubmed/33542378
http://dx.doi.org/10.1038/s41598-021-82647-w

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