Cargando…

Gene regulation contributes to explain the impact of early life socioeconomic disadvantage on adult inflammatory levels in two cohort studies

Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. To address this, we explore the relationship a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Carmeli, Cristian, Kutalik, Zoltán, Mishra, Pashupati P., Porcu, Eleonora, Delpierre, Cyrille, Delaneau, Olivier, Kelly-Irving, Michelle, Bochud, Murielle, Dhayat, Nasser A., Ponte, Belen, Pruijm, Menno, Ehret, Georg, Kähönen, Mika, Lehtimäki, Terho, Raitakari, Olli T., Vineis, Paolo, Kivimäki, Mika, Chadeau-Hyam, Marc, Dermitzakis, Emmanouil, Vuilleumier, Nicolas, Stringhini, Silvia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862626/ https://www.ncbi.nlm.nih.gov/pubmed/33542415 http://dx.doi.org/10.1038/s41598-021-82714-2

Ejemplares similares

Reproductive history and blood cell DNA methylation later in life: the Young Finns Study
por: Harville, Emily W., et al.
Publicado: (2021)

Changes of lipoprotein(a) levels with endogenous steroid hormones
por: Tessitore, Elena, et al.
Publicado: (2021)

Patterning of educational attainment across inflammatory markers: Findings from a multi-cohort study
por: Maurel, Marine, et al.
Publicado: (2020)

Multi-Omics Integration in a Twin Cohort and Predictive Modeling of Blood Pressure Values
por: Drouard, Gabin, et al.
Publicado: (2022)

Multi-cohort study identifies social determinants of systemic inflammation over the life course
por: Berger, Eloïse, et al.
Publicado: (2019)

Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases
por: Mishra, Pashupati P., et al.
Publicado: (2023)

Assessment of plasma ceramides as predictor for subclinical atherosclerosis
por: Mishra, Pashupati P., et al.
Publicado: (2021)

Heritability and association with distinct genetic loci of erythropoietin levels in the general population
por: Corre, Tanguy, et al.
Publicado: (2021)

The effect of apolipoprotein E polymorphism on serum metabolome – a population-based 10-year follow-up study
por: Karjalainen, Juho-Pekka, et al.
Publicado: (2019)

Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods
por: Lehtimäki, Miikael, et al.
Publicado: (2023)

Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
por: Mishra, Binisha H., et al.
Publicado: (2021)

Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
por: Hulkkonen, Janne, et al.
Publicado: (2014)

Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health
por: Marttila, Saara, et al.
Publicado: (2021)

Epigenome-450K-wide methylation signatures of active cigarette smoking: The Young Finns Study
por: Mishra, Pashupati P., et al.
Publicado: (2020)

Education, biological ageing, all-cause and cause-specific mortality and morbidity: UK biobank cohort study
por: Chadeau-Hyam, Marc, et al.
Publicado: (2020)

Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
por: Ackermann, Daniel, et al.
Publicado: (2019)

Correction: Reference intervals for the urinary steroid metabolome: The impact of sex, age, day and night time on human adult steroidogenesis
por: Ackermann, Daniel, et al.
Publicado: (2021)

Sex- and age-specific reference intervals for diagnostic ratios reflecting relative activity of steroidogenic enzymes and pathways in adults
por: Rousson, Valentin, et al.
Publicado: (2021)

The relationship of trait-like compassion with epigenetic aging: The population-based prospective Young Finns Study
por: Dobewall, Henrik, et al.
Publicado: (2023)

Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study
por: Kivimäki, Mika, et al.
Publicado: (2008)

Neighbourhood socioeconomic disadvantage, risk factors, and diabetes from childhood to middle age in the Young Finns Study: a cohort study
por: Kivimäki, Mika, et al.
Publicado: (2018)

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study
por: Jylhävä, Juulia, et al.
Publicado: (2012)

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults
por: Würtz, Peter, et al.
Publicado: (2013)

Cross-sectionally Calculated Metabolic Aging Does Not Relate to Longitudinal Metabolic Changes—Support for Stratified Aging Models
por: Ala-Korpela, Mika, et al.
Publicado: (2023)

Socioeconomic indicators in epidemiologic research: A practical example from the LIFEPATH study
por: d’Errico, Angelo, et al.
Publicado: (2017)

Examining the effect of mitochondrial DNA variants on blood pressure in two Finnish cohorts
por: Laaksonen, Jaakko, et al.
Publicado: (2021)

Urinary steroid profiling in women hints at a diagnostic signature of the polycystic ovary syndrome: A pilot study considering neglected steroid metabolites
por: Dhayat, Nasser A., et al.
Publicado: (2018)

Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study
por: Stringhini, Silvia, et al.
Publicado: (2018)

Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women
por: Stringhini, Silvia, et al.
Publicado: (2017)

Longitudinal metabolomics of increasing body-mass index and waist-hip ratio reveals two dynamic patterns of obesity pandemic
por: Mäkinen, Ville-Petteri, et al.
Publicado: (2023)

Cardiometabolic Health Among Adult Offspring of Hypertensive Pregnancies: The Cardiovascular Risk in Young Finns Study
por: Tapp, Robyn J., et al.
Publicado: (2018)

Genetic variation in the hTAS2R38 taste receptor and food consumption among Finnish adults
por: Sandell, Mari, et al.
Publicado: (2014)

A new blood based epigenetic age predictor for adolescents and young adults
por: Aanes, Håvard, et al.
Publicado: (2023)

Whole blood microRNA levels associate with glycemic status and correlate with target mRNAs in pathways important to type 2 diabetes
por: Mononen, Nina, et al.
Publicado: (2019)

Prospective Relationship of Change in Ideal Cardiovascular Health Status and Arterial Stiffness: The Cardiovascular Risk in Young Finns Study
por: Aatola, Heikki, et al.
Publicado: (2014)

The biomarker and causal roles of homoarginine in the development of cardiometabolic diseases: an observational and Mendelian randomization analysis
por: Seppälä, Ilkka, et al.
Publicado: (2017)

Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study
por: Campbell, Matthew D., et al.
Publicado: (2018)

Allostatic load and subsequent all-cause mortality: which biological markers drive the relationship? Findings from a UK birth cohort
por: Castagné, Raphaële, et al.
Publicado: (2018)

NAFLD risk alleles in PNPLA3, TM6SF2, GCKR and LYPLAL1 show divergent metabolic effects
por: Sliz, Eeva, et al.
Publicado: (2018)

Exploring Causality between TV Viewing and Weight Change in Young and Middle-Aged Adults. The Cardiovascular Risk in Young Finns Study
por: Helajärvi, Harri, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_c27kndni1dp8tc18nf6lbgv59t