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The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring
While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspri...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862650/ https://www.ncbi.nlm.nih.gov/pubmed/33542173 http://dx.doi.org/10.1038/s41398-021-01208-x |
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author | Wong, Gerard Weir, Jacquelyn M. Mishra, Priti Huynh, Kevin Nijagal, Brunda Gupta, Varsha Broekman, Birit F. P. Chong, Mary Foong-Fong Chan, Shiao-Yng Tan, Kok Hian Tull, Dedreia McConville, Malcolm Calder, Philip C. Godfrey, Keith M. Chong, Yap Seng Gluckman, Peter D. Meaney, Michael J. Meikle, Peter J. Karnani, Neerja |
author_facet | Wong, Gerard Weir, Jacquelyn M. Mishra, Priti Huynh, Kevin Nijagal, Brunda Gupta, Varsha Broekman, Birit F. P. Chong, Mary Foong-Fong Chan, Shiao-Yng Tan, Kok Hian Tull, Dedreia McConville, Malcolm Calder, Philip C. Godfrey, Keith M. Chong, Yap Seng Gluckman, Peter D. Meaney, Michael J. Meikle, Peter J. Karnani, Neerja |
author_sort | Wong, Gerard |
collection | PubMed |
description | While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. |
format | Online Article Text |
id | pubmed-7862650 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-78626502021-02-16 The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring Wong, Gerard Weir, Jacquelyn M. Mishra, Priti Huynh, Kevin Nijagal, Brunda Gupta, Varsha Broekman, Birit F. P. Chong, Mary Foong-Fong Chan, Shiao-Yng Tan, Kok Hian Tull, Dedreia McConville, Malcolm Calder, Philip C. Godfrey, Keith M. Chong, Yap Seng Gluckman, Peter D. Meaney, Michael J. Meikle, Peter J. Karnani, Neerja Transl Psychiatry Article While maternal mental health strongly influences neurodevelopment and health in the offspring, little is known about the determinants of inter-individual variation in the mental health of mothers. Likewise, the in utero biological pathways by which variation in maternal mental health affects offspring development remain to be defined. Previous studies implicate lipids, consistent with a known influence on cognitive and emotional function, but the relevance for maternal mental health and offspring neurodevelopment is unclear. This study characterizes the placental and circulatory lipids in antenatal depression, as well as socio-emotional outcomes in the offspring. Targeted liquid chromatography-mass spectrometry covering 470 lipid species was performed on placenta from 186 women with low (n = 70) or high (n = 116) levels of antenatal depressive symptoms assessed using the Edinburgh Postnatal Depression Scale at 26 weeks’ gestation. Child socio-emotional outcomes were assessed from the Child Behavior Check List (CBCL) at 48 months. Seventeen placental lipid species showed an inverse association with antenatal EPDS scores. Specifically, lower levels of phospholipids containing LC-PUFAs: omega-3 docosapentaenoic acid (DPA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and omega-6 arachidonic acid (AA) were significantly associated with depressive symptoms. Additional measurement of LC-PUFA in antenatal plasma samples at mid-gestation confirmed the reduced circulation of these specific fatty acids in mothers. Reduced concentration of the placental phospholipids also predicted poorer socio-emotional outcomes in the offspring. This study provides new insights into the role of the materno-fetal lipid cross-talk as a mechanism linking maternal mental health to that of the offspring. These findings show the potential utility of nutritional approaches among pregnant women with depressive symptoms to reduce offspring risk for later socio-emotional problems. Nature Publishing Group UK 2021-02-04 /pmc/articles/PMC7862650/ /pubmed/33542173 http://dx.doi.org/10.1038/s41398-021-01208-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Wong, Gerard Weir, Jacquelyn M. Mishra, Priti Huynh, Kevin Nijagal, Brunda Gupta, Varsha Broekman, Birit F. P. Chong, Mary Foong-Fong Chan, Shiao-Yng Tan, Kok Hian Tull, Dedreia McConville, Malcolm Calder, Philip C. Godfrey, Keith M. Chong, Yap Seng Gluckman, Peter D. Meaney, Michael J. Meikle, Peter J. Karnani, Neerja The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title | The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title_full | The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title_fullStr | The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title_full_unstemmed | The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title_short | The placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
title_sort | placental lipidome of maternal antenatal depression predicts socio-emotional problems in the offspring |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862650/ https://www.ncbi.nlm.nih.gov/pubmed/33542173 http://dx.doi.org/10.1038/s41398-021-01208-x |
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