Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions

Adenosine-to-inosine (A-to-I) editing of eukaryotic cellular RNAs is essential for protection against auto-immune disorders. Editing is carried out by ADAR1, whose innate immune response-specific cytoplasmic isoform possesses a Z-DNA binding domain (Zα) of unknown function. Zα also binds to CpG repe...

Descripción completa

Detalles Bibliográficos
Autores principales: Nichols, Parker J., Bevers, Shaun, Henen, Morkos, Kieft, Jeffrey S., Vicens, Quentin, Vögeli, Beat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862695/
https://www.ncbi.nlm.nih.gov/pubmed/33542240
http://dx.doi.org/10.1038/s41467-021-21039-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862695/
https://www.ncbi.nlm.nih.gov/pubmed/33542240
http://dx.doi.org/10.1038/s41467-021-21039-0

Ejemplares similares