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Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation

Pyroptosis, one kind of inflammatory regulated cell death, is involved in various inflammatory diseases, including acute kidney injury (AKI). Besides Gasdermin D (GSDMD), GSDME is a newly identified mediator of pyroptosis via the cleavage of caspase-3 generating pyroptotic GSDME-N. Here, we investig...

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Detalles Bibliográficos
Autores principales:	Xia, Weiwei, Li, Yuanyuan, Wu, Mengying, Jin, Qianqian, Wang, Qian, Li, Shuzhen, Huang, Songming, Zhang, Aihua, Zhang, Yue, Jia, Zhanjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862699/ https://www.ncbi.nlm.nih.gov/pubmed/33542198 http://dx.doi.org/10.1038/s41419-021-03431-2

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