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Relative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium

PURPOSE: Bis-retinoids are a major component of lipofuscin that accumulates in the retinal pigment epithelium (RPE) in aging and age-related macular degeneration (AMD). Although bis-retinoids are known to originate from retinaldehydes required for the light response of photoreceptor cells, the relat...

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Detalles Bibliográficos
Autores principales:	Boyer, Nicholas P., Thompson, Debra A., Koutalos, Yiannis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2021
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862733/ https://www.ncbi.nlm.nih.gov/pubmed/33523199 http://dx.doi.org/10.1167/iovs.62.2.1

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