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Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project

Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by Campylobacter spp., which has been ass...

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Autores principales: Chen, Dehao, McKune, Sarah L., Singh, Nitya, Yousuf Hassen, Jemal, Gebreyes, Wondwossen, Manary, Mark J., Bardosh, Kevin, Yang, Yang, Diaz, Nicholas, Mohammed, Abdulmuen, Terefe, Yitagele, Roba, Kedir Teji, Ketema, Mengistu, Ameha, Negassi, Assefa, Nega, Rajashekara, Gireesh, Deblais, Loïc, Ghanem, Mostafa, Yimer, Getnet, Havelaar, Arie H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862945/
https://www.ncbi.nlm.nih.gov/pubmed/33553097
http://dx.doi.org/10.3389/fpubh.2020.615793
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author Chen, Dehao
McKune, Sarah L.
Singh, Nitya
Yousuf Hassen, Jemal
Gebreyes, Wondwossen
Manary, Mark J.
Bardosh, Kevin
Yang, Yang
Diaz, Nicholas
Mohammed, Abdulmuen
Terefe, Yitagele
Roba, Kedir Teji
Ketema, Mengistu
Ameha, Negassi
Assefa, Nega
Rajashekara, Gireesh
Deblais, Loïc
Ghanem, Mostafa
Yimer, Getnet
Havelaar, Arie H.
author_facet Chen, Dehao
McKune, Sarah L.
Singh, Nitya
Yousuf Hassen, Jemal
Gebreyes, Wondwossen
Manary, Mark J.
Bardosh, Kevin
Yang, Yang
Diaz, Nicholas
Mohammed, Abdulmuen
Terefe, Yitagele
Roba, Kedir Teji
Ketema, Mengistu
Ameha, Negassi
Assefa, Nega
Rajashekara, Gireesh
Deblais, Loïc
Ghanem, Mostafa
Yimer, Getnet
Havelaar, Arie H.
author_sort Chen, Dehao
collection PubMed
description Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by Campylobacter spp., which has been associated with Environmental Enteric Dysfunction (EED) and stunting. A cross-sectional study involving 102 randomly selected children between 12 and 16 months of age was conducted in rural eastern Ethiopia to establish prevalence rates of Campylobacter colonization, EED, and stunting, and evaluate potential risk factors. Data were collected between September and December 2018. The prevalence of EED and stunting was 50% (95% CI: 40–60%) and 41% (95% CI: 32–51%), respectively. Among enrolled children, 56% had consumed some ASF in the previous 24 h; 47% had diarrhea and 50% had fever in the past 15 days. 54, 63, 71 or 43% of households owned at least one chicken, cow/bull, goat, or sheep; 54 (53%) households kept chickens indoors overnight and only half of these confined the animals. Sanitation was poor, with high levels of unimproved latrines and open defecation. Most households had access to an improved source of drinking water. The prevalence of Campylobacter colonization was 50% (95% CI: 41–60%) by PCR. In addition to the thermotolerant species Campylobacter jejuni, Campylobacter coli and Campylobacter upsaliensis, non-thermotolerant species related to Campylobacter hyointestinalis and Campylobacter fetus were frequently detected by Meta-total RNA sequencing (MeTRS). Current breastfeeding and ASF consumption increased the odds of Campylobacter detection by PCR, while improved drinking water supply decreased the odds of EED. No risk factors were significantly associated with stunting. Further studies are necessary to better understand reservoirs and transmission pathways of Campylobacter spp. and their potential impact on child health.
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spelling pubmed-78629452021-02-06 Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project Chen, Dehao McKune, Sarah L. Singh, Nitya Yousuf Hassen, Jemal Gebreyes, Wondwossen Manary, Mark J. Bardosh, Kevin Yang, Yang Diaz, Nicholas Mohammed, Abdulmuen Terefe, Yitagele Roba, Kedir Teji Ketema, Mengistu Ameha, Negassi Assefa, Nega Rajashekara, Gireesh Deblais, Loïc Ghanem, Mostafa Yimer, Getnet Havelaar, Arie H. Front Public Health Public Health Livestock farming provides a possible mechanism by which smallholder farmers can meet their household need for animal source foods (ASF), which may reduce the risk of stunting. However, direct/indirect contacts with domestic animals may increase colonization by Campylobacter spp., which has been associated with Environmental Enteric Dysfunction (EED) and stunting. A cross-sectional study involving 102 randomly selected children between 12 and 16 months of age was conducted in rural eastern Ethiopia to establish prevalence rates of Campylobacter colonization, EED, and stunting, and evaluate potential risk factors. Data were collected between September and December 2018. The prevalence of EED and stunting was 50% (95% CI: 40–60%) and 41% (95% CI: 32–51%), respectively. Among enrolled children, 56% had consumed some ASF in the previous 24 h; 47% had diarrhea and 50% had fever in the past 15 days. 54, 63, 71 or 43% of households owned at least one chicken, cow/bull, goat, or sheep; 54 (53%) households kept chickens indoors overnight and only half of these confined the animals. Sanitation was poor, with high levels of unimproved latrines and open defecation. Most households had access to an improved source of drinking water. The prevalence of Campylobacter colonization was 50% (95% CI: 41–60%) by PCR. In addition to the thermotolerant species Campylobacter jejuni, Campylobacter coli and Campylobacter upsaliensis, non-thermotolerant species related to Campylobacter hyointestinalis and Campylobacter fetus were frequently detected by Meta-total RNA sequencing (MeTRS). Current breastfeeding and ASF consumption increased the odds of Campylobacter detection by PCR, while improved drinking water supply decreased the odds of EED. No risk factors were significantly associated with stunting. Further studies are necessary to better understand reservoirs and transmission pathways of Campylobacter spp. and their potential impact on child health. Frontiers Media S.A. 2021-01-21 /pmc/articles/PMC7862945/ /pubmed/33553097 http://dx.doi.org/10.3389/fpubh.2020.615793 Text en Copyright © 2021 Chen, McKune, Singh, Yousuf Hassen, Gebreyes, Manary, Bardosh, Yang, Diaz, Mohammed, Terefe, Roba, Ketema, Ameha, Assefa, Rajashekara, Deblais, Ghanem, Yimer and Havelaar. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Chen, Dehao
McKune, Sarah L.
Singh, Nitya
Yousuf Hassen, Jemal
Gebreyes, Wondwossen
Manary, Mark J.
Bardosh, Kevin
Yang, Yang
Diaz, Nicholas
Mohammed, Abdulmuen
Terefe, Yitagele
Roba, Kedir Teji
Ketema, Mengistu
Ameha, Negassi
Assefa, Nega
Rajashekara, Gireesh
Deblais, Loïc
Ghanem, Mostafa
Yimer, Getnet
Havelaar, Arie H.
Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title_full Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title_fullStr Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title_full_unstemmed Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title_short Campylobacter Colonization, Environmental Enteric Dysfunction, Stunting, and Associated Risk Factors Among Young Children in Rural Ethiopia: A Cross-Sectional Study From the Campylobacter Genomics and Environmental Enteric Dysfunction (CAGED) Project
title_sort campylobacter colonization, environmental enteric dysfunction, stunting, and associated risk factors among young children in rural ethiopia: a cross-sectional study from the campylobacter genomics and environmental enteric dysfunction (caged) project
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862945/
https://www.ncbi.nlm.nih.gov/pubmed/33553097
http://dx.doi.org/10.3389/fpubh.2020.615793
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