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Expression and clinical significance of CMTM1 in hepatocellular carcinoma

BACKGROUND: CKLF Like Marvel Transmembrane Domain Containing 1 (CMTM1) plays a role in breast cancer and lung cancer, but studies on the occurrence and development of CMTM1 in hepatocellular carcinoma (HCC) have not been reported. METHODS: The Cancer Genome Atlas (TCGA) database and immunohistochemi...

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Autores principales: Song, Xin, Zhang, Shidong, Tian, Run, Zheng, Chuanjun, Xu, Yuge, Wang, Tianxian, Bei, Chunhua, Zhang, Huixia, He, Xiao, Zhu, Xiaonian, Tan, Shengkui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: De Gruyter 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862999/
https://www.ncbi.nlm.nih.gov/pubmed/33585698
http://dx.doi.org/10.1515/med-2021-0221
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author Song, Xin
Zhang, Shidong
Tian, Run
Zheng, Chuanjun
Xu, Yuge
Wang, Tianxian
Bei, Chunhua
Zhang, Huixia
He, Xiao
Zhu, Xiaonian
Tan, Shengkui
author_facet Song, Xin
Zhang, Shidong
Tian, Run
Zheng, Chuanjun
Xu, Yuge
Wang, Tianxian
Bei, Chunhua
Zhang, Huixia
He, Xiao
Zhu, Xiaonian
Tan, Shengkui
author_sort Song, Xin
collection PubMed
description BACKGROUND: CKLF Like Marvel Transmembrane Domain Containing 1 (CMTM1) plays a role in breast cancer and lung cancer, but studies on the occurrence and development of CMTM1 in hepatocellular carcinoma (HCC) have not been reported. METHODS: The Cancer Genome Atlas (TCGA) database and immunohistochemistry (IHC) were used to detect CMTM1 expression in HCC tissues. The relationship between CMTM1 expression and the clinicopathological characteristics of HCC patients was analyzed by chi-square test, and the relationship between CMTM1 expression and the prognosis of HCC patients was tested by the Kaplan–Meier model. RESULTS: Bioinformatics analysis showed that the mRNA expression of CMTM1 was upregulated in HCC tissues, and low expression of CMTM1 is associated with longer disease-free survival in patients with HCC. Similarly, the survival time of HCC patients in CMTM1 high expression group was significantly shorter than that in CMTM1 low expression group. IHC detection indicated that CMTM1 protein was highly expressed in both HCC and adjacent non-tumor tissues, with a positive expression in 84% (63/75) of HCC tissues and 89.3% (67/75) of adjacent non-tumor tissues. Moreover, CMTM1 expression was related to family history and TNM stage of HCC patients (P < 0.05), but had no relationship with other clinicopathological characteristics. The survival analysis based on IHC results showed that the prognosis of HCC patients in CMTM1 negative group was significantly poorer than that in CMTM1 positive group (P < 0.05). CONCLUSION: CMTM1 has a high expression in HCC tissues and is related to the prognosis of HCC patients.
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spelling pubmed-78629992021-02-12 Expression and clinical significance of CMTM1 in hepatocellular carcinoma Song, Xin Zhang, Shidong Tian, Run Zheng, Chuanjun Xu, Yuge Wang, Tianxian Bei, Chunhua Zhang, Huixia He, Xiao Zhu, Xiaonian Tan, Shengkui Open Med (Wars) Research Article BACKGROUND: CKLF Like Marvel Transmembrane Domain Containing 1 (CMTM1) plays a role in breast cancer and lung cancer, but studies on the occurrence and development of CMTM1 in hepatocellular carcinoma (HCC) have not been reported. METHODS: The Cancer Genome Atlas (TCGA) database and immunohistochemistry (IHC) were used to detect CMTM1 expression in HCC tissues. The relationship between CMTM1 expression and the clinicopathological characteristics of HCC patients was analyzed by chi-square test, and the relationship between CMTM1 expression and the prognosis of HCC patients was tested by the Kaplan–Meier model. RESULTS: Bioinformatics analysis showed that the mRNA expression of CMTM1 was upregulated in HCC tissues, and low expression of CMTM1 is associated with longer disease-free survival in patients with HCC. Similarly, the survival time of HCC patients in CMTM1 high expression group was significantly shorter than that in CMTM1 low expression group. IHC detection indicated that CMTM1 protein was highly expressed in both HCC and adjacent non-tumor tissues, with a positive expression in 84% (63/75) of HCC tissues and 89.3% (67/75) of adjacent non-tumor tissues. Moreover, CMTM1 expression was related to family history and TNM stage of HCC patients (P < 0.05), but had no relationship with other clinicopathological characteristics. The survival analysis based on IHC results showed that the prognosis of HCC patients in CMTM1 negative group was significantly poorer than that in CMTM1 positive group (P < 0.05). CONCLUSION: CMTM1 has a high expression in HCC tissues and is related to the prognosis of HCC patients. De Gruyter 2021-01-28 /pmc/articles/PMC7862999/ /pubmed/33585698 http://dx.doi.org/10.1515/med-2021-0221 Text en © 2021 Xin Song et al., published by De Gruyter http://creativecommons.org/licenses/by/4.0 This work is licensed under the Creative Commons Attribution 4.0 International License.
spellingShingle Research Article
Song, Xin
Zhang, Shidong
Tian, Run
Zheng, Chuanjun
Xu, Yuge
Wang, Tianxian
Bei, Chunhua
Zhang, Huixia
He, Xiao
Zhu, Xiaonian
Tan, Shengkui
Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title_full Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title_fullStr Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title_full_unstemmed Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title_short Expression and clinical significance of CMTM1 in hepatocellular carcinoma
title_sort expression and clinical significance of cmtm1 in hepatocellular carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862999/
https://www.ncbi.nlm.nih.gov/pubmed/33585698
http://dx.doi.org/10.1515/med-2021-0221
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