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Template-assisted design of monomeric polyQ models to unravel the unique role of glutamine side chains in disease-related aggregation
Expanded polyglutamine (polyQ) sequences cause numerous neurodegenerative diseases which are accompanied by the formation of polyQ fibrils. The unique role of glutamines in the aggregation onset is undoubtedly accepted and a lot structural data of the fibrils have been acquired, however side-chain s...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863018/ https://www.ncbi.nlm.nih.gov/pubmed/33552461 http://dx.doi.org/10.1039/d0sc05299j |