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Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Brazilian Society of Assisted Reproduction
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863088/ https://www.ncbi.nlm.nih.gov/pubmed/32569454 http://dx.doi.org/10.5935/1518-0557.20200044 |
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author | Behmanesh, Mohammad Amin Poormoosavi, Seyedeh Mahsa pareidar, Yousef ghorbanzadeh, Behnam Mahmoodi-kouhi, Ahmad Najafzadehvarzi, Hossein |
author_facet | Behmanesh, Mohammad Amin Poormoosavi, Seyedeh Mahsa pareidar, Yousef ghorbanzadeh, Behnam Mahmoodi-kouhi, Ahmad Najafzadehvarzi, Hossein |
author_sort | Behmanesh, Mohammad Amin |
collection | PubMed |
description | OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage by streptozotocin (STZ)-induced DM in rats. METHODS: We ran this experimental study on 40 adult female Wistar rats. We divided the animals into five groups, control (A); DM (STZ by 60 mg/kg- intraperitoneally) (B); DM + hexane extract of P. atlantica (200 mg/kg -orally) (C); P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and we administered the extract daily. After slaughtering the rats, we removed the ovaries. We assessed parameters, such as blood glucose and levels of oxidative stress markers as well as histological ovary structure. RESULTS: Blood glucose, malondialdehyde (MDA) levels, and the number of atretic follicles were elevated; catalase (CAT), superoxide dismutase (SOD) levels and the number of corpora lutea were significantly decreased in the untreated diabetic rats. These changes returned to normal or diminished with P. atlantica extract and glibenclamide in the treated rats. CONCLUSIONS: The extract of P. atlantica has antihyperglycemic and antioxidative properties, and it decreased ovarian complications in experimental diabetes mellitus. |
format | Online Article Text |
id | pubmed-7863088 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Brazilian Society of Assisted Reproduction |
record_format | MEDLINE/PubMed |
spelling | pubmed-78630882021-02-10 Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats Behmanesh, Mohammad Amin Poormoosavi, Seyedeh Mahsa pareidar, Yousef ghorbanzadeh, Behnam Mahmoodi-kouhi, Ahmad Najafzadehvarzi, Hossein JBRA Assist Reprod Original Article OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage by streptozotocin (STZ)-induced DM in rats. METHODS: We ran this experimental study on 40 adult female Wistar rats. We divided the animals into five groups, control (A); DM (STZ by 60 mg/kg- intraperitoneally) (B); DM + hexane extract of P. atlantica (200 mg/kg -orally) (C); P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and we administered the extract daily. After slaughtering the rats, we removed the ovaries. We assessed parameters, such as blood glucose and levels of oxidative stress markers as well as histological ovary structure. RESULTS: Blood glucose, malondialdehyde (MDA) levels, and the number of atretic follicles were elevated; catalase (CAT), superoxide dismutase (SOD) levels and the number of corpora lutea were significantly decreased in the untreated diabetic rats. These changes returned to normal or diminished with P. atlantica extract and glibenclamide in the treated rats. CONCLUSIONS: The extract of P. atlantica has antihyperglycemic and antioxidative properties, and it decreased ovarian complications in experimental diabetes mellitus. Brazilian Society of Assisted Reproduction 2021 /pmc/articles/PMC7863088/ /pubmed/32569454 http://dx.doi.org/10.5935/1518-0557.20200044 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Behmanesh, Mohammad Amin Poormoosavi, Seyedeh Mahsa pareidar, Yousef ghorbanzadeh, Behnam Mahmoodi-kouhi, Ahmad Najafzadehvarzi, Hossein Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title | Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title_full | Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title_fullStr | Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title_full_unstemmed | Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title_short | Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
title_sort | pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863088/ https://www.ncbi.nlm.nih.gov/pubmed/32569454 http://dx.doi.org/10.5935/1518-0557.20200044 |
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