Cargando…

Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats

OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage...

Descripción completa

Detalles Bibliográficos
Autores principales: Behmanesh, Mohammad Amin, Poormoosavi, Seyedeh Mahsa, pareidar, Yousef, ghorbanzadeh, Behnam, Mahmoodi-kouhi, Ahmad, Najafzadehvarzi, Hossein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brazilian Society of Assisted Reproduction 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863088/
https://www.ncbi.nlm.nih.gov/pubmed/32569454
http://dx.doi.org/10.5935/1518-0557.20200044
_version_ 1783647433448751104
author Behmanesh, Mohammad Amin
Poormoosavi, Seyedeh Mahsa
pareidar, Yousef
ghorbanzadeh, Behnam
Mahmoodi-kouhi, Ahmad
Najafzadehvarzi, Hossein
author_facet Behmanesh, Mohammad Amin
Poormoosavi, Seyedeh Mahsa
pareidar, Yousef
ghorbanzadeh, Behnam
Mahmoodi-kouhi, Ahmad
Najafzadehvarzi, Hossein
author_sort Behmanesh, Mohammad Amin
collection PubMed
description OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage by streptozotocin (STZ)-induced DM in rats. METHODS: We ran this experimental study on 40 adult female Wistar rats. We divided the animals into five groups, control (A); DM (STZ by 60 mg/kg- intraperitoneally) (B); DM + hexane extract of P. atlantica (200 mg/kg -orally) (C); P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and we administered the extract daily. After slaughtering the rats, we removed the ovaries. We assessed parameters, such as blood glucose and levels of oxidative stress markers as well as histological ovary structure. RESULTS: Blood glucose, malondialdehyde (MDA) levels, and the number of atretic follicles were elevated; catalase (CAT), superoxide dismutase (SOD) levels and the number of corpora lutea were significantly decreased in the untreated diabetic rats. These changes returned to normal or diminished with P. atlantica extract and glibenclamide in the treated rats. CONCLUSIONS: The extract of P. atlantica has antihyperglycemic and antioxidative properties, and it decreased ovarian complications in experimental diabetes mellitus.
format Online
Article
Text
id pubmed-7863088
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Brazilian Society of Assisted Reproduction
record_format MEDLINE/PubMed
spelling pubmed-78630882021-02-10 Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats Behmanesh, Mohammad Amin Poormoosavi, Seyedeh Mahsa pareidar, Yousef ghorbanzadeh, Behnam Mahmoodi-kouhi, Ahmad Najafzadehvarzi, Hossein JBRA Assist Reprod Original Article OBJECTIVE: Diabetes mellitus (DM) is associated with numerous complications, including gonadal dysfunction. There are specific traditional medicine remedies for DM, including medicinal herbs. Our study aimed to evaluate the role of Pistacia atlantica’s extract in the protection against ovary damage by streptozotocin (STZ)-induced DM in rats. METHODS: We ran this experimental study on 40 adult female Wistar rats. We divided the animals into five groups, control (A); DM (STZ by 60 mg/kg- intraperitoneally) (B); DM + hexane extract of P. atlantica (200 mg/kg -orally) (C); P. atlantica extract (D) and DM + glibenclamide (200 mg/kg -orally) (F). The experiment continued for four weeks, and we administered the extract daily. After slaughtering the rats, we removed the ovaries. We assessed parameters, such as blood glucose and levels of oxidative stress markers as well as histological ovary structure. RESULTS: Blood glucose, malondialdehyde (MDA) levels, and the number of atretic follicles were elevated; catalase (CAT), superoxide dismutase (SOD) levels and the number of corpora lutea were significantly decreased in the untreated diabetic rats. These changes returned to normal or diminished with P. atlantica extract and glibenclamide in the treated rats. CONCLUSIONS: The extract of P. atlantica has antihyperglycemic and antioxidative properties, and it decreased ovarian complications in experimental diabetes mellitus. Brazilian Society of Assisted Reproduction 2021 /pmc/articles/PMC7863088/ /pubmed/32569454 http://dx.doi.org/10.5935/1518-0557.20200044 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Behmanesh, Mohammad Amin
Poormoosavi, Seyedeh Mahsa
pareidar, Yousef
ghorbanzadeh, Behnam
Mahmoodi-kouhi, Ahmad
Najafzadehvarzi, Hossein
Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title_full Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title_fullStr Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title_full_unstemmed Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title_short Pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
title_sort pistacia atlantica's effect on ovary damage and oxidative stress in streptozotocin-induced diabetic rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863088/
https://www.ncbi.nlm.nih.gov/pubmed/32569454
http://dx.doi.org/10.5935/1518-0557.20200044
work_keys_str_mv AT behmaneshmohammadamin pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats
AT poormoosaviseyedehmahsa pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats
AT pareidaryousef pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats
AT ghorbanzadehbehnam pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats
AT mahmoodikouhiahmad pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats
AT najafzadehvarzihossein pistaciaatlanticaseffectonovarydamageandoxidativestressinstreptozotocininduceddiabeticrats