Effectiveness of the use of Low Molecular Heparin in patients with repetition abortion history: Systematic review and meta-analysis

OBJECTIVE: To evaluate the efficacy and safety of using low molecular weight heparin (LMWH) in women with a history of recurrent abortion without an identified cause. METHODS: To develop a systematic review to select the studies. Total found 437 papers. Seven studies were completed or requested. The following variables were analyzed: clinical pregnancy, implantation rate, live births, abortion, premature birth, pregnancy, continuous pregnancy, beyond the 20(th) gestational week, congenital abnormality, hemorrhage, preeclampsia, placental premature detachment. RESULTS: The LMWH group had a higher incidence of continuous pregnancy after the 20(th) week of gestation and there was no significant difference between the LMWH group and the expectant management group in the analysis of other variables. CONCLUSIONS: There was no data showing risk and/or less use of LMWH compared to expectant management; on the contrary, LMWH use increased the incidence of evolutionary pregnancy after the 20(th) gestational week. LMWH has some influence on prophylactic treatment of repeat abortion for unknown cause.