Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020

Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (3...

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Detalles Bibliográficos
Autores principales: Jeffery-Smith, Anna, Iyanger, Nalini, Williams, Sarah V, Chow, J Yimmy, Aiano, Felicity, Hoschler, Katja, Lackenby, Angie, Ellis, Joanna, Platt, Steven, Miah, Shahjahan, Brown, Kevin, Amirthalingam, Gayatri, Patel, Monika, Ramsay, Mary E, Gopal, Robin, Charlett, Andre, Ladhani, Shamez N, Zambon, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863231/
https://www.ncbi.nlm.nih.gov/pubmed/33541486
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.5.2100092
Descripción
Sumario:Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model.

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