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Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020
Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (3...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863231/ https://www.ncbi.nlm.nih.gov/pubmed/33541486 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.5.2100092 |
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| author | Jeffery-Smith, Anna Iyanger, Nalini Williams, Sarah V Chow, J Yimmy Aiano, Felicity Hoschler, Katja Lackenby, Angie Ellis, Joanna Platt, Steven Miah, Shahjahan Brown, Kevin Amirthalingam, Gayatri Patel, Monika Ramsay, Mary E Gopal, Robin Charlett, Andre Ladhani, Shamez N Zambon, Maria |
| author_facet | Jeffery-Smith, Anna Iyanger, Nalini Williams, Sarah V Chow, J Yimmy Aiano, Felicity Hoschler, Katja Lackenby, Angie Ellis, Joanna Platt, Steven Miah, Shahjahan Brown, Kevin Amirthalingam, Gayatri Patel, Monika Ramsay, Mary E Gopal, Robin Charlett, Andre Ladhani, Shamez N Zambon, Maria |
| author_sort | Jeffery-Smith, Anna |
| collection | PubMed |
| description | Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model. |
| format | Online Article Text |
| id | pubmed-7863231 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | European Centre for Disease Prevention and Control (ECDC) |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-78632312021-02-10 Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 Jeffery-Smith, Anna Iyanger, Nalini Williams, Sarah V Chow, J Yimmy Aiano, Felicity Hoschler, Katja Lackenby, Angie Ellis, Joanna Platt, Steven Miah, Shahjahan Brown, Kevin Amirthalingam, Gayatri Patel, Monika Ramsay, Mary E Gopal, Robin Charlett, Andre Ladhani, Shamez N Zambon, Maria Euro Surveill Rapid Communication Two London care homes experienced a second COVID-19 outbreak, with 29/209 (13.9%) SARS-CoV-2 RT-PCR-positive cases (16/103 residents, 13/106 staff). In those with prior SARS-CoV-2 exposure, 1/88 (1.1%) individuals (antibody positive: 87; RT-PCR-positive: 1) became PCR-positive compared with 22/73 (30.1%) with confirmed seronegative status. After four months protection offered by prior infection against re-infection was 96.2% (95% confidence interval (CI): 72.7–99.5%) using risk ratios from comparison of proportions and 96.1% (95% CI: 78.8–99.3%) using a penalised logistic regression model. European Centre for Disease Prevention and Control (ECDC) 2021-02-04 /pmc/articles/PMC7863231/ /pubmed/33541486 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.5.2100092 Text en This article is copyright of the authors or their affiliated institutions, 2021. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
| spellingShingle | Rapid Communication Jeffery-Smith, Anna Iyanger, Nalini Williams, Sarah V Chow, J Yimmy Aiano, Felicity Hoschler, Katja Lackenby, Angie Ellis, Joanna Platt, Steven Miah, Shahjahan Brown, Kevin Amirthalingam, Gayatri Patel, Monika Ramsay, Mary E Gopal, Robin Charlett, Andre Ladhani, Shamez N Zambon, Maria Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title | Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title_full | Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title_fullStr | Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title_full_unstemmed | Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title_short | Antibodies to SARS-CoV-2 protect against re-infection during outbreaks in care homes, September and October 2020 |
| title_sort | antibodies to sars-cov-2 protect against re-infection during outbreaks in care homes, september and october 2020 |
| topic | Rapid Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863231/ https://www.ncbi.nlm.nih.gov/pubmed/33541486 http://dx.doi.org/10.2807/1560-7917.ES.2021.26.5.2100092 |
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