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Most colitis associated carcinomas lack expression of LGR5: a preliminary study with implications for unique pathways of carcinogenesis compared to sporadic colorectal carcinoma

BACKGROUND: Leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), a component of the Wnt receptor complex, is thought to lineage label gastric and intestinal stem cells. LGR5 expression is increased in colorectal carcinoma (CRC) compared to normal tissue. Colitis associated colorectal...

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Detalles Bibliográficos
Autores principales:	Iwaya, Mai, Ota, Hiroyoshi, Nakajima, Tomoyuki, Uehara, Takeshi, Riddell, Robert, Conner, James
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863293/ https://www.ncbi.nlm.nih.gov/pubmed/33541282 http://dx.doi.org/10.1186/s12885-021-07835-3

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