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The Role of the Persistent Sodium Current in Epilepsy
Voltage-gated sodium channels (VGSCs) are foundational to excitable cell function: Their coordinated passage of sodium ions into the cell is critical for the generation and propagation of action potentials throughout the nervous system. The classical paradigm of action potential physiology states th...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863310/ https://www.ncbi.nlm.nih.gov/pubmed/33236643 http://dx.doi.org/10.1177/1535759720973978 |
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author | Wengert, Eric R. Patel, Manoj K. |
author_facet | Wengert, Eric R. Patel, Manoj K. |
author_sort | Wengert, Eric R. |
collection | PubMed |
description | Voltage-gated sodium channels (VGSCs) are foundational to excitable cell function: Their coordinated passage of sodium ions into the cell is critical for the generation and propagation of action potentials throughout the nervous system. The classical paradigm of action potential physiology states that sodium passes through the membrane only transiently (1-2 milliseconds), before the channels inactivate and cease to conduct sodium ions. However, in reality, a small fraction of the total sodium current (1%-2%) remains at steady state despite prolonged depolarization. While this persistent sodium current (I(NaP)) contributes to normal physiological functioning of neurons, accumulating evidence indicates a particularly pathogenic role for an elevated I(NaP) in epilepsy (reviewed previously(1)). Due to significant advances over the past decade of epilepsy research concerning the importance of I(NaP) in sodium channelopathies, this review seeks to summarize recent evidence and highlight promising novel anti-seizure medication strategies through preferentially targeting I(NaP). |
format | Online Article Text |
id | pubmed-7863310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-78633102021-02-16 The Role of the Persistent Sodium Current in Epilepsy Wengert, Eric R. Patel, Manoj K. Epilepsy Curr Current Review in Basic Science Voltage-gated sodium channels (VGSCs) are foundational to excitable cell function: Their coordinated passage of sodium ions into the cell is critical for the generation and propagation of action potentials throughout the nervous system. The classical paradigm of action potential physiology states that sodium passes through the membrane only transiently (1-2 milliseconds), before the channels inactivate and cease to conduct sodium ions. However, in reality, a small fraction of the total sodium current (1%-2%) remains at steady state despite prolonged depolarization. While this persistent sodium current (I(NaP)) contributes to normal physiological functioning of neurons, accumulating evidence indicates a particularly pathogenic role for an elevated I(NaP) in epilepsy (reviewed previously(1)). Due to significant advances over the past decade of epilepsy research concerning the importance of I(NaP) in sodium channelopathies, this review seeks to summarize recent evidence and highlight promising novel anti-seizure medication strategies through preferentially targeting I(NaP). SAGE Publications 2020-11-25 /pmc/articles/PMC7863310/ /pubmed/33236643 http://dx.doi.org/10.1177/1535759720973978 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Current Review in Basic Science Wengert, Eric R. Patel, Manoj K. The Role of the Persistent Sodium Current in Epilepsy |
title | The Role of the Persistent Sodium Current in Epilepsy |
title_full | The Role of the Persistent Sodium Current in Epilepsy |
title_fullStr | The Role of the Persistent Sodium Current in Epilepsy |
title_full_unstemmed | The Role of the Persistent Sodium Current in Epilepsy |
title_short | The Role of the Persistent Sodium Current in Epilepsy |
title_sort | role of the persistent sodium current in epilepsy |
topic | Current Review in Basic Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863310/ https://www.ncbi.nlm.nih.gov/pubmed/33236643 http://dx.doi.org/10.1177/1535759720973978 |
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