Beclin‐1‐mediated activation of autophagy improves proximal and distal urea cycle disorders

Urea cycle disorders (UCD) are inherited defects in clearance of waste nitrogen with high morbidity and mortality. Novel and more effective therapies for UCD are needed. Studies in mice with constitutive activation of autophagy unravelled Beclin‐1 as druggable candidate for therapy of hyperammonemia...

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Detalles Bibliográficos
Autores principales: Soria, Leandro R, Gurung, Sonam, De Sabbata, Giulia, Perocheau, Dany P, De Angelis, Angela, Bruno, Gemma, Polishchuk, Elena, Paris, Debora, Cuomo, Paola, Motta, Andrea, Orford, Michael, Khalil, Youssef, Eaton, Simon, Mills, Philippa B, Waddington, Simon N, Settembre, Carmine, Muro, Andrés F, Baruteau, Julien, Brunetti‐Pierri, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863400/
https://www.ncbi.nlm.nih.gov/pubmed/33369168
http://dx.doi.org/10.15252/emmm.202013158

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