Cargando…

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

BACKGROUND: Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated protein kinase (AMPK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Troncoso, Mayarling Francisca, Pavez, Mario, Wilson, Carlos, Lagos, Daniel, Duran, Javier, Ramos, Sebastián, Barrientos, Genaro, Silva, Patricio, Llanos, Paola, Basualto-Alarcón, Carla, Westenbrink, B. Daan, Lavandero, Sergio, Estrada, Manuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863443/ https://www.ncbi.nlm.nih.gov/pubmed/33546773 http://dx.doi.org/10.1186/s40659-021-00328-4

Ejemplares similares

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy
por: Duran, Javier, et al.
Publicado: (2016)

Ca(2+)/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy
por: Duran, Javier, et al.
Publicado: (2017)

Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men
por: Basualto-Alarcón, Carla, et al.
Publicado: (2021)

Androgen-Regulated Cardiac Metabolism in Aging Men
por: Barrientos, Genaro, et al.
Publicado: (2020)

GDF11 Modulates Ca(2+)-Dependent Smad2/3 Signaling to Prevent Cardiomyocyte Hypertrophy
por: Duran, Javier, et al.
Publicado: (2018)

NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle
por: Jorquera, Gonzalo, et al.
Publicado: (2021)

Sarcopenia and Androgens: A Link between Pathology and Treatment
por: Basualto-Alarcón, Carla, et al.
Publicado: (2014)

AKIP1, a Cardiac Hypertrophy Induced Protein that Stimulates Cardiomyocyte Growth via the Akt Pathway
por: Yu, Hongjuan, et al.
Publicado: (2013)

Crosstalk between AMPK activation and angiotensin II-induced hypertrophy in cardiomyocytes: the role of mitochondria
por: Hernández, Jessica Soto, et al.
Publicado: (2014)

An α(2)-adrenoceptor agonist: Dexmedetomidine induces protective cardiomyocyte hypertrophy through mitochondrial-AMPK pathway
por: Weng, Xiaojian, et al.
Publicado: (2020)

IGF-1 boosts mitochondrial function by a Ca(2+) uptake-dependent mechanism in cultured human and rat cardiomyocytes
por: Sánchez-Aguilera, Pablo, et al.
Publicado: (2023)

Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy
por: Fernández, Carolina, et al.
Publicado: (2021)

EGCG Blocked Phenylephrin-Induced Hypertrophy in H9C2 Cardiomyocytes, by Activating AMPK-Dependent Pathway
por: Cai, Yi, et al.
Publicado: (2015)

Myristate induces mitochondrial fragmentation and cardiomyocyte hypertrophy through mitochondrial E3 ubiquitin ligase MUL1
por: Vásquez-Trincado, César, et al.
Publicado: (2023)

Cardiomyocyte death: mechanisms and translational implications
por: Chiong, M, et al.
Publicado: (2011)

Testosterone enables growth and hypertrophy in fusion impaired myoblasts that display myotube atrophy: deciphering the role of androgen and IGF-I receptors
por: Hughes, David C., et al.
Publicado: (2015)

Testosterone Antagonizes Doxorubicin‐Induced Senescence of Cardiomyocytes
por: Altieri, Paola, et al.
Publicado: (2016)

Selenoprotein DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPRmt in Human Cardiomyocytes
por: Bomer, Nils, et al.
Publicado: (2021)

Cordyceps militaris Fruit Body Extract Decreases Testosterone Catabolism and Testosterone-Stimulated Prostate Hypertrophy
por: Kusama, Kazuya, et al.
Publicado: (2020)

Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy
por: Rosales, Wendy, et al.
Publicado: (2016)

Lycopene Inhibits Urotensin-II-Induced Cardiomyocyte Hypertrophy in Neonatal Rat Cardiomyocytes
por: Chao, Hung-Hsing, et al.
Publicado: (2014)

Renal Hypertrophy in Mice Receiving Estrogens and Androgens
por: Pfeiffer, Carroll A., et al.
Publicado: (1940)

The role of androgens in pressure overload myocardial hypertrophy
por: Schafstedde, Marie, et al.
Publicado: (2023)

Shengmai Injection Suppresses Angiotensin II-Induced Cardiomyocyte Hypertrophy and Apoptosis via Activation of the AMPK Signaling Pathway Through Energy-Dependent Mechanisms
por: Li, Yiping, et al.
Publicado: (2019)

Testosterone Recovery after Androgen Deprivation Therapy in Prostate Cancer: Building a Predictive Model
por: Borque-Fernando, Ángel, et al.
Publicado: (2023)

Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological Strategies
por: Muñoz-Córdova, Felipe, et al.
Publicado: (2021)

Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy
por: Kooij, Viola, et al.
Publicado: (2016)

AKIP1 Expression Modulates Mitochondrial Function in Rat Neonatal Cardiomyocytes
por: Yu, Hongjuan, et al.
Publicado: (2013)

The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration
por: Thomson, David M.
Publicado: (2018)

Partial Androgen Deficiency, Depression, and Testosterone Supplementation in Aging Men
por: Amore, Mario, et al.
Publicado: (2012)

Serum testosterone level correlates with left ventricular hypertrophy in older women
por: Szadkowska, Iwona, et al.
Publicado: (2023)

Pioglitazone Induces Cardiomyocyte Apoptosis and Inhibits Cardiomyocyte Hypertrophy Via VEGFR-2 Signaling Pathway
por: Zhong, Wenliang, et al.
Publicado: (2018)

Cardiomyocyte BRAF and type 1 RAF inhibitors promote cardiomyocyte and cardiac hypertrophy in mice in vivo
por: Clerk, Angela, et al.
Publicado: (2022)

ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca(2+) Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
por: Pavez-Giani, Mario G., et al.
Publicado: (2021)

Genetic Variation in the Androgen Receptor and Measures of Plasma Testosterone Levels Suggest Androgen Dysfunction in Alzheimer’s Disease
por: Carr, Jessie S., et al.
Publicado: (2018)

Stauntonia hexaphylla Extract Ameliorates Androgenic Alopecia by Inhibiting Androgen Signaling in Testosterone-induced Alopecia Mice
por: Hong, Geum-Lan, et al.
Publicado: (2023)

A potential role of autophagy-mediated vascular senescence in the pathophysiology of HFpEF
por: Sanhueza-Olivares, Fernanda, et al.
Publicado: (2022)

Endothelial activation impairs the function of small extracellular vesicles
por: Herrera-Zelada, Nicolas, et al.
Publicado: (2023)

Importance of measuring testosterone in enzyme-inhibited plasma for oral testosterone undecanoate androgen replacement therapy clinical trials
por: Lachance, Sylvain, et al.
Publicado: (2015)

NAP1L5 Promotes Nucleolar Hypertrophy and Is Required for Translation Activation During Cardiomyocyte Hypertrophy
por: Guo, Ningning, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_84p4hv50t4eri0lffdarj2vhf8