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Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment
BACKGROUND: The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits a high signal-to-background ratio, deep tissue penetration and maximum permiss...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863535/ https://www.ncbi.nlm.nih.gov/pubmed/33541369 http://dx.doi.org/10.1186/s12951-021-00782-y |
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author | Xu, Yunjian Wang, Shiqi Chen, Zhenjiang Hu, Rui Li, Shaoqiang Zhao, Yihua Liu, Liwei Qu, Junle |
author_facet | Xu, Yunjian Wang, Shiqi Chen, Zhenjiang Hu, Rui Li, Shaoqiang Zhao, Yihua Liu, Liwei Qu, Junle |
author_sort | Xu, Yunjian |
collection | PubMed |
description | BACKGROUND: The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits a high signal-to-background ratio, deep tissue penetration and maximum permissible light power, which can minimize damage to an organism during photoinduced tumor therapy. RESULTS: A class of stable NIR-II fluorophores (NIR998, NIR1028, NIR980, NIR1030, and NIR1028-S) based on aza–boron–dipyrromethene (aza-BODIPY) dyes with donor–acceptor-donor structures have been rationally designed and synthesized by harnessing the steric relaxation effect and intramolecular photoinduced electron transfer (IPET). These fluorophores exhibit an intense range of NIR-II emission, large Stokes shift (≥ 100 nm), excellent photothermal conversion performance, and superior stability against photobleaching. Among the NIR-II fluorophores, NIR998 possesses better NIR-II emission and photothermal conversion performance. NIR998 nanoparticles (NIR998 NPs) can be encapsulated by liposomes. NIR998 NPs show superior stability in the presence of light, heat, and reactive oxygen nitrogen species than that of indocyanine green NPs, as well as a higher photothermal conversion ability (η = 50.5%) compared to other photothermal agents. Finally, under the guidance of photothermal imaging, NIR998 NPs have been proven to effectively eliminate tumors via their excellent photothermal conversion performance while presenting negligible cytotoxicity. CONCLUSIONS: Utilizing IPET and the steric relaxation effect can effectively induce NIR-II emission of aza-BODIPY dyes. Stable NIR998 NPs have excellent photothermal conversion performance and negligible dark cytotoxicity, so they have the potential to act as photothermal agents in biological applications. [Image: see text] |
format | Online Article Text |
id | pubmed-7863535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-78635352021-02-08 Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment Xu, Yunjian Wang, Shiqi Chen, Zhenjiang Hu, Rui Li, Shaoqiang Zhao, Yihua Liu, Liwei Qu, Junle J Nanobiotechnology Research BACKGROUND: The aim to develop a highly stable near-infrared (NIR) photoinduced tumor therapy agent stems from its considerable potential for biological application. Due to its long wavelength, biological imaging exhibits a high signal-to-background ratio, deep tissue penetration and maximum permissible light power, which can minimize damage to an organism during photoinduced tumor therapy. RESULTS: A class of stable NIR-II fluorophores (NIR998, NIR1028, NIR980, NIR1030, and NIR1028-S) based on aza–boron–dipyrromethene (aza-BODIPY) dyes with donor–acceptor-donor structures have been rationally designed and synthesized by harnessing the steric relaxation effect and intramolecular photoinduced electron transfer (IPET). These fluorophores exhibit an intense range of NIR-II emission, large Stokes shift (≥ 100 nm), excellent photothermal conversion performance, and superior stability against photobleaching. Among the NIR-II fluorophores, NIR998 possesses better NIR-II emission and photothermal conversion performance. NIR998 nanoparticles (NIR998 NPs) can be encapsulated by liposomes. NIR998 NPs show superior stability in the presence of light, heat, and reactive oxygen nitrogen species than that of indocyanine green NPs, as well as a higher photothermal conversion ability (η = 50.5%) compared to other photothermal agents. Finally, under the guidance of photothermal imaging, NIR998 NPs have been proven to effectively eliminate tumors via their excellent photothermal conversion performance while presenting negligible cytotoxicity. CONCLUSIONS: Utilizing IPET and the steric relaxation effect can effectively induce NIR-II emission of aza-BODIPY dyes. Stable NIR998 NPs have excellent photothermal conversion performance and negligible dark cytotoxicity, so they have the potential to act as photothermal agents in biological applications. [Image: see text] BioMed Central 2021-02-04 /pmc/articles/PMC7863535/ /pubmed/33541369 http://dx.doi.org/10.1186/s12951-021-00782-y Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Xu, Yunjian Wang, Shiqi Chen, Zhenjiang Hu, Rui Li, Shaoqiang Zhao, Yihua Liu, Liwei Qu, Junle Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title | Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title_full | Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title_fullStr | Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title_full_unstemmed | Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title_short | Highly stable organic photothermal agent based on near-infrared-II fluorophores for tumor treatment |
title_sort | highly stable organic photothermal agent based on near-infrared-ii fluorophores for tumor treatment |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863535/ https://www.ncbi.nlm.nih.gov/pubmed/33541369 http://dx.doi.org/10.1186/s12951-021-00782-y |
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