Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report

Here we presented a case of a 19-month-old boy who developed severe aplastic anemia postacute hepatitis. He was treated successfully with the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) infusion and cyclosporine A (CsA). The boy achieved both hematopoietic recovery and normal lymphocy...

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Autores principales: Fang, Liu, Meikuang, Lim, Ye, Guo, Xiaojuan, Chen, Wenyu, Yang, Min, Ruan, Lixian, Chang, Weiqiang, Wang, Zhibo, Han, Zhongchao, Han, Xiaofan, Zhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863554/
https://www.ncbi.nlm.nih.gov/pubmed/33525921
http://dx.doi.org/10.1177/0963689720977144
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author Fang, Liu
Meikuang, Lim
Ye, Guo
Xiaojuan, Chen
Wenyu, Yang
Min, Ruan
Lixian, Chang
Weiqiang, Wang
Zhibo, Han
Zhongchao, Han
Xiaofan, Zhu
author_facet Fang, Liu
Meikuang, Lim
Ye, Guo
Xiaojuan, Chen
Wenyu, Yang
Min, Ruan
Lixian, Chang
Weiqiang, Wang
Zhibo, Han
Zhongchao, Han
Xiaofan, Zhu
author_sort Fang, Liu
collection PubMed
description Here we presented a case of a 19-month-old boy who developed severe aplastic anemia postacute hepatitis. He was treated successfully with the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) infusion and cyclosporine A (CsA). The boy achieved both hematopoietic recovery and normal lymphocyte proportion. So far, his condition still remains stable. To our knowledge, there is a rare previous report on the utility of MSCs infusion for the treatment of hepatitis-associated aplastic anemia (HAAA). Considering the efficacy, safety, and strong operability, particularly for pediatric patient, the infusion of UC-MSCs combined with CsA could be an effective alternative for the treatment of HAAA.
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spelling pubmed-78635542021-02-16 Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report Fang, Liu Meikuang, Lim Ye, Guo Xiaojuan, Chen Wenyu, Yang Min, Ruan Lixian, Chang Weiqiang, Wang Zhibo, Han Zhongchao, Han Xiaofan, Zhu Cell Transplant Case Study Here we presented a case of a 19-month-old boy who developed severe aplastic anemia postacute hepatitis. He was treated successfully with the umbilical cord-derived mesenchymal stromal cells (UC-MSCs) infusion and cyclosporine A (CsA). The boy achieved both hematopoietic recovery and normal lymphocyte proportion. So far, his condition still remains stable. To our knowledge, there is a rare previous report on the utility of MSCs infusion for the treatment of hepatitis-associated aplastic anemia (HAAA). Considering the efficacy, safety, and strong operability, particularly for pediatric patient, the infusion of UC-MSCs combined with CsA could be an effective alternative for the treatment of HAAA. SAGE Publications 2021-02-02 /pmc/articles/PMC7863554/ /pubmed/33525921 http://dx.doi.org/10.1177/0963689720977144 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Study
Fang, Liu
Meikuang, Lim
Ye, Guo
Xiaojuan, Chen
Wenyu, Yang
Min, Ruan
Lixian, Chang
Weiqiang, Wang
Zhibo, Han
Zhongchao, Han
Xiaofan, Zhu
Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title_full Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title_fullStr Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title_full_unstemmed Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title_short Successful Treatment of a 19-Month-Old Boy with Hepatitis Associated Aplastic Anemia by Infusion of Umbilical Cord-Derived Mesenchymal Stromal Cells: A Case Report
title_sort successful treatment of a 19-month-old boy with hepatitis associated aplastic anemia by infusion of umbilical cord-derived mesenchymal stromal cells: a case report
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863554/
https://www.ncbi.nlm.nih.gov/pubmed/33525921
http://dx.doi.org/10.1177/0963689720977144
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