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Brd4 regulates NLRC4 inflammasome activation by facilitating IRF8-mediated transcription of Naips

NLRC4 inflammasome activation and the subsequent maturation of IL-1β and IL-18 are critical for protection against infection by bacterial pathogens. The epigenetic regulator Brd4 has emerged as a key player in inflammation by regulating the expression of inflammatory cytokines. However, whether Brd4...

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Detalles Bibliográficos
Autores principales:	Dong, Xingchen, Hu, Xiangming, Bao, Yan, Li, Guo, Yang, Xiao-dong, Slauch, James M., Chen, Lin-Feng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863722/ https://www.ncbi.nlm.nih.gov/pubmed/33535228 http://dx.doi.org/10.1083/jcb.202005148

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