Complement activity is regulated in C3 glomerulopathy by IgG–factor H fusion proteins with and without properdin targeting domains

C3 glomerulopathy is characterized by accumulation of complement C3 within glomeruli. Causes include, but are not limited to, abnormalities in factor H, the major negative regulator of the complement alternative pathway. Factor H-deficient (Cfh(-/-)) mice develop C3 glomerulopathy together with a re...

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Detalles Bibliográficos
Autores principales: Gilmore, Alyssa C., Zhang, Yuchun, Cook, H. Terence, Lavin, Deborah P., Katti, Suresh, Wang, Yi, Johnson, Krista K., Kim, SungKwon, Pickering, Matthew C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Basic Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863913/
https://www.ncbi.nlm.nih.gov/pubmed/33129896
http://dx.doi.org/10.1016/j.kint.2020.09.028

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