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Importance of Cx43 for Right Ventricular Function
In the heart, connexins form gap junctions, hemichannels, and are also present within mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles. Whereas the role of Cx43 is well established for the healthy and diseased left ventricle, less is known about the importanc...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863922/ https://www.ncbi.nlm.nih.gov/pubmed/33498172 http://dx.doi.org/10.3390/ijms22030987 |
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author | Boengler, Kerstin Rohrbach, Susanne Weissmann, Norbert Schulz, Rainer |
author_facet | Boengler, Kerstin Rohrbach, Susanne Weissmann, Norbert Schulz, Rainer |
author_sort | Boengler, Kerstin |
collection | PubMed |
description | In the heart, connexins form gap junctions, hemichannels, and are also present within mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles. Whereas the role of Cx43 is well established for the healthy and diseased left ventricle, less is known about the importance of Cx43 for the development of right ventricular (RV) dysfunction. The present article focusses on the importance of Cx43 for the developing heart. Furthermore, we discuss the expression and localization of Cx43 in the diseased RV, i.e., in the tetralogy of Fallot and in pulmonary hypertension, in which the RV is affected, and RV hypertrophy and failure occur. We will also introduce other Cx molecules that are expressed in RV and surrounding tissues and have been reported to be involved in RV pathophysiology. Finally, we highlight therapeutic strategies aiming to improve RV function in pulmonary hypertension that are associated with alterations of Cx43 expression and function. |
format | Online Article Text |
id | pubmed-7863922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78639222021-02-06 Importance of Cx43 for Right Ventricular Function Boengler, Kerstin Rohrbach, Susanne Weissmann, Norbert Schulz, Rainer Int J Mol Sci Review In the heart, connexins form gap junctions, hemichannels, and are also present within mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles. Whereas the role of Cx43 is well established for the healthy and diseased left ventricle, less is known about the importance of Cx43 for the development of right ventricular (RV) dysfunction. The present article focusses on the importance of Cx43 for the developing heart. Furthermore, we discuss the expression and localization of Cx43 in the diseased RV, i.e., in the tetralogy of Fallot and in pulmonary hypertension, in which the RV is affected, and RV hypertrophy and failure occur. We will also introduce other Cx molecules that are expressed in RV and surrounding tissues and have been reported to be involved in RV pathophysiology. Finally, we highlight therapeutic strategies aiming to improve RV function in pulmonary hypertension that are associated with alterations of Cx43 expression and function. MDPI 2021-01-20 /pmc/articles/PMC7863922/ /pubmed/33498172 http://dx.doi.org/10.3390/ijms22030987 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Boengler, Kerstin Rohrbach, Susanne Weissmann, Norbert Schulz, Rainer Importance of Cx43 for Right Ventricular Function |
title | Importance of Cx43 for Right Ventricular Function |
title_full | Importance of Cx43 for Right Ventricular Function |
title_fullStr | Importance of Cx43 for Right Ventricular Function |
title_full_unstemmed | Importance of Cx43 for Right Ventricular Function |
title_short | Importance of Cx43 for Right Ventricular Function |
title_sort | importance of cx43 for right ventricular function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863922/ https://www.ncbi.nlm.nih.gov/pubmed/33498172 http://dx.doi.org/10.3390/ijms22030987 |
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