Cargando…
Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds
Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts in both industry and academia. In the last two decades, the interest in biocatalytic transformations has increased due to an urgent need for more sustainable industrial processes that comply with the pri...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863935/ https://www.ncbi.nlm.nih.gov/pubmed/33498198 http://dx.doi.org/10.3390/ijms22030990 |
_version_ | 1783647572391362560 |
---|---|
author | Santi, Micol Sancineto, Luca Nascimento, Vanessa Braun Azeredo, Juliano Orozco, Erika V. M. Andrade, Leandro H. Gröger, Harald Santi, Claudio |
author_facet | Santi, Micol Sancineto, Luca Nascimento, Vanessa Braun Azeredo, Juliano Orozco, Erika V. M. Andrade, Leandro H. Gröger, Harald Santi, Claudio |
author_sort | Santi, Micol |
collection | PubMed |
description | Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts in both industry and academia. In the last two decades, the interest in biocatalytic transformations has increased due to an urgent need for more sustainable industrial processes that comply with the principles of green chemistry. Thanks to the recent advances in biotechnologies, protein engineering and the Nobel prize awarded concept of direct enzymatic evolution, the synthetic enzymatic toolbox has expanded significantly. In particular, the implementation of biocatalysts in continuous flow systems has attracted much attention, especially from industry. The advantages of flow chemistry enable biosynthesis to overcome well-known limitations of “classic” enzymatic catalysis, such as time-consuming work-ups and enzyme inhibition, as well as difficult scale-up and process intensifications. Moreover, continuous flow biocatalysis provides access to practical, economical and more sustainable synthetic pathways, an important aspect for the future of pharmaceutical companies if they want to compete in the market while complying with European Medicines Agency (EMA), Food and Drug Administration (FDA) and green chemistry requirements. This review focuses on the most recent advances in the use of flow biocatalysis for the synthesis of active pharmaceutical ingredients (APIs), pharmaceuticals and natural products, and the advantages and limitations are discussed. |
format | Online Article Text |
id | pubmed-7863935 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78639352021-02-06 Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds Santi, Micol Sancineto, Luca Nascimento, Vanessa Braun Azeredo, Juliano Orozco, Erika V. M. Andrade, Leandro H. Gröger, Harald Santi, Claudio Int J Mol Sci Review Biocatalysts represent an efficient, highly selective and greener alternative to metal catalysts in both industry and academia. In the last two decades, the interest in biocatalytic transformations has increased due to an urgent need for more sustainable industrial processes that comply with the principles of green chemistry. Thanks to the recent advances in biotechnologies, protein engineering and the Nobel prize awarded concept of direct enzymatic evolution, the synthetic enzymatic toolbox has expanded significantly. In particular, the implementation of biocatalysts in continuous flow systems has attracted much attention, especially from industry. The advantages of flow chemistry enable biosynthesis to overcome well-known limitations of “classic” enzymatic catalysis, such as time-consuming work-ups and enzyme inhibition, as well as difficult scale-up and process intensifications. Moreover, continuous flow biocatalysis provides access to practical, economical and more sustainable synthetic pathways, an important aspect for the future of pharmaceutical companies if they want to compete in the market while complying with European Medicines Agency (EMA), Food and Drug Administration (FDA) and green chemistry requirements. This review focuses on the most recent advances in the use of flow biocatalysis for the synthesis of active pharmaceutical ingredients (APIs), pharmaceuticals and natural products, and the advantages and limitations are discussed. MDPI 2021-01-20 /pmc/articles/PMC7863935/ /pubmed/33498198 http://dx.doi.org/10.3390/ijms22030990 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Santi, Micol Sancineto, Luca Nascimento, Vanessa Braun Azeredo, Juliano Orozco, Erika V. M. Andrade, Leandro H. Gröger, Harald Santi, Claudio Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title | Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title_full | Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title_fullStr | Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title_full_unstemmed | Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title_short | Flow Biocatalysis: A Challenging Alternative for the Synthesis of APIs and Natural Compounds |
title_sort | flow biocatalysis: a challenging alternative for the synthesis of apis and natural compounds |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7863935/ https://www.ncbi.nlm.nih.gov/pubmed/33498198 http://dx.doi.org/10.3390/ijms22030990 |
work_keys_str_mv | AT santimicol flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT sancinetoluca flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT nascimentovanessa flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT braunazeredojuliano flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT orozcoerikavm flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT andradeleandroh flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT grogerharald flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds AT santiclaudio flowbiocatalysisachallengingalternativeforthesynthesisofapisandnaturalcompounds |