Cargando…

HMGA2-induced epithelial–mesenchymal transition is reversed by let-7d in intrauterine adhesions

Intrauterine adhesions (IUAs), the leading cause of uterine infertility, are characterized by endometrial fibrosis. The management of IUA is challenging because the pathogenesis of the disease largely unknown. In this study, we demonstrate that the mRNA and protein levels of high mobility group AT-h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Minmin, Cao, Chenrui, Zhou, Zhenhua, Yao, Simin, Jiang, Peipei, Wang, Huiyan, Zhao, Guangfeng, Hu, Yali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864003/ https://www.ncbi.nlm.nih.gov/pubmed/33237328 http://dx.doi.org/10.1093/molehr/gaaa074

Ejemplares similares

Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma
por: Wu, Aibing, et al.
Publicado: (2015)

Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
por: Yao, Simin, et al.
Publicado: (2023)

Let-7c inhibits migration and epithelial–mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2
por: Hou, Bo, et al.
Publicado: (2018)

HMGA2 induces epithelial-to-mesenchymal transition in human hepatocellular carcinoma cells
por: LUO, YIZHOU, et al.
Publicado: (2013)

Transforming growth factor-β employs HMGA2 to elicit epithelial–mesenchymal transition
por: Thuault, Sylvie, et al.
Publicado: (2006)

HMGA1 and HMGA2 expression and comparative analyses of HMGA2, Lin28 and let-7 miRNAs in oral squamous cell carcinoma
por: Sterenczak, Katharina Anna, et al.
Publicado: (2014)

ΔNp63α-induced DUSP4/GSK3β/SNAI1 pathway in epithelial cells drives endometrial fibrosis
por: Zhao, Guangfeng, et al.
Publicado: (2020)

Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma
por: Shi, Guizhi, et al.
Publicado: (2009)

MicroRNA Let-7d-3p Contributes to Cardiac Protection via Targeting HMGA2
por: Wong, Lee Lee, et al.
Publicado: (2019)

Down-regulation of PBK inhibits proliferation of human endometrial stromal cells in thin endometrium
por: Zhu, Qi, et al.
Publicado: (2022)

HMGA2 is associated with epithelial–mesenchymal transition and can predict poor prognosis in nasopharyngeal carcinoma
por: Xia, You-You, et al.
Publicado: (2015)

Involvement of epithelial–mesenchymal transition in liver fibrosis
por: Yu, Kangkang, et al.
Publicado: (2018)

Dulaglutide Ameliorates Intrauterine Adhesion by Suppressing Inflammation and Epithelial–Mesenchymal Transition via Inhibiting the TGF-β/Smad2 Signaling Pathway
por: Wang, Yifan, et al.
Publicado: (2023)

let-7i inhibits proliferation and migration of bladder cancer cells by targeting HMGA1
por: Qin, M-M, et al.
Publicado: (2019)

Let-7, Lin28 and Hmga2 Expression in Ciliary Epithelium and Retinal Progenitor Cells
por: Frasson, Lorena Teixeira, et al.
Publicado: (2021)

Deciphering the endometrial niche of human thin endometrium at single-cell resolution
por: Lv, Haining, et al.
Publicado: (2022)

Heat shock protein 90 is involved in the regulation of HMGA2-driven growth and epithelial-to-mesenchymal transition of colorectal cancer cells
por: Kao, Chun-Yu, et al.
Publicado: (2016)

HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-β/Smad2 signaling pathway
por: Kou, Bo, et al.
Publicado: (2018)

Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation
por: Rahman, M M, et al.
Publicado: (2009)

Let-7 Represses Carcinogenesis and a Stem Cell Phenotype in the Intestine via Regulation of Hmga2
por: Madison, Blair B., et al.
Publicado: (2015)

Developmental regulation of myeloerythroid progenitor function by the Lin28b–let-7–Hmga2 axis
por: Rowe, R. Grant, et al.
Publicado: (2016)

Let-7b-5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2
por: Huang, Yujing, et al.
Publicado: (2021)

FSH stimulates expression of the embryonic gene HMGA2 by downregulating let-7 in normal fimbrial epithelial cells of ovarian high-grade serous carcinomas
por: ZHANG, XU-YIN, et al.
Publicado: (2013)

Lin28 Induces Epithelial-to-Mesenchymal Transition and Stemness via Downregulation of Let-7a in Breast Cancer Cells
por: Liu, Yujie, et al.
Publicado: (2013)

Let-7d and miR-185 Impede Epithelial-Mesenchymal Transition by Downregulating Rab25 in Breast Cancer
por: Shahabi, Arman, et al.
Publicado: (2021)

High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial Neoplasia
por: Unachukwu, Uchenna, et al.
Publicado: (2020)

miR-98-5p Alleviated Epithelial-to-Mesenchymal Transition and Renal Fibrosis via Targeting Hmga2 in Diabetic Nephropathy
por: Zhu, Yingchun, et al.
Publicado: (2019)

Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation
por: Qiu, Feng, et al.
Publicado: (2022)

Effects of HMGA2 on the epithelial-mesenchymal transition-related genes in ACHN renal cell carcinoma cells-derived xenografts in nude mice
por: Liu, Ying, et al.
Publicado: (2022)

IGF2BP2 Promotes Epithelial to Mesenchymal Transition and Metastasis through Stabilizing HMGA1 mRNA in Gastric Cancer
por: Ouyang, Jun, et al.
Publicado: (2022)

METTL3-mediated m(6)A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial–mesenchymal transition
por: Wang, Yuwei, et al.
Publicado: (2023)

TRIM71 suppresses tumorigenesis via modulation of Lin28B-let-7-HMGA2 signaling
por: Yin, Jinlong, et al.
Publicado: (2016)

Let-7a-5p may participate in the pathogenesis of diabetic nephropathy through targeting HMGA2
por: Wang, Tao, et al.
Publicado: (2019)

Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo
por: Segal, Meirav, et al.
Publicado: (2019)

miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis
por: Yu, Xinghao, et al.
Publicado: (2019)

circPTPN12/miR-21–5 p/∆Np63α pathway contributes to human endometrial fibrosis
por: Song, Minmin, et al.
Publicado: (2021)

Boolean modeling of mechanosensitive epithelial to mesenchymal transition and its reversal
por: Sullivan, Emmalee, et al.
Publicado: (2023)

Let-7c regulated epithelial-mesenchymal transition leads to osimertinib resistance in NSCLC cells with EGFR T790M mutations
por: Li, Xiao-Feng, et al.
Publicado: (2020)

Efficacy of Intrauterine Device in the Treatment of Intrauterine Adhesions
por: Salma, Umme, et al.
Publicado: (2014)

MicroRNA-4458 suppresses migration and epithelial–mesenchymal transition via targeting HMGA1 in non-small-cell lung cancer cells
por: Ma, Yu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_e7j77uj3it55mpnkhkfbmohkb6