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Selenium Compounds as Novel Potential Anticancer Agents

The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establ...

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Autores principales: Radomska, Dominika, Czarnomysy, Robert, Radomski, Dominik, Bielawski, Krzysztof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864035/
https://www.ncbi.nlm.nih.gov/pubmed/33498364
http://dx.doi.org/10.3390/ijms22031009
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author Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawski, Krzysztof
author_facet Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawski, Krzysztof
author_sort Radomska, Dominika
collection PubMed
description The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol.
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spelling pubmed-78640352021-02-06 Selenium Compounds as Novel Potential Anticancer Agents Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawski, Krzysztof Int J Mol Sci Review The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol. MDPI 2021-01-20 /pmc/articles/PMC7864035/ /pubmed/33498364 http://dx.doi.org/10.3390/ijms22031009 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Radomska, Dominika
Czarnomysy, Robert
Radomski, Dominik
Bielawski, Krzysztof
Selenium Compounds as Novel Potential Anticancer Agents
title Selenium Compounds as Novel Potential Anticancer Agents
title_full Selenium Compounds as Novel Potential Anticancer Agents
title_fullStr Selenium Compounds as Novel Potential Anticancer Agents
title_full_unstemmed Selenium Compounds as Novel Potential Anticancer Agents
title_short Selenium Compounds as Novel Potential Anticancer Agents
title_sort selenium compounds as novel potential anticancer agents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864035/
https://www.ncbi.nlm.nih.gov/pubmed/33498364
http://dx.doi.org/10.3390/ijms22031009
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