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Selenium Compounds as Novel Potential Anticancer Agents
The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establ...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864035/ https://www.ncbi.nlm.nih.gov/pubmed/33498364 http://dx.doi.org/10.3390/ijms22031009 |
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author | Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawski, Krzysztof |
author_facet | Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawski, Krzysztof |
author_sort | Radomska, Dominika |
collection | PubMed |
description | The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol. |
format | Online Article Text |
id | pubmed-7864035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78640352021-02-06 Selenium Compounds as Novel Potential Anticancer Agents Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawski, Krzysztof Int J Mol Sci Review The high number of new cancer incidences and the associated mortality continue to be alarming, leading to the search for new therapies that would be more effective and less burdensome for patients. As there is evidence that Se compounds can have chemopreventive activity, studies have begun to establish whether these compounds can also affect already existing cancers. This review aims to discuss the different classes of Se-containing compounds, both organic and inorganic, natural and synthetic, and the mechanisms and molecular targets of their anticancer activity. The chemical classes discussed in this paper include inorganic (selenite, selenate) and organic compounds, such as diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one and selenophene-based derivatives, as well as selenoamino acids and Selol. MDPI 2021-01-20 /pmc/articles/PMC7864035/ /pubmed/33498364 http://dx.doi.org/10.3390/ijms22031009 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Radomska, Dominika Czarnomysy, Robert Radomski, Dominik Bielawski, Krzysztof Selenium Compounds as Novel Potential Anticancer Agents |
title | Selenium Compounds as Novel Potential Anticancer Agents |
title_full | Selenium Compounds as Novel Potential Anticancer Agents |
title_fullStr | Selenium Compounds as Novel Potential Anticancer Agents |
title_full_unstemmed | Selenium Compounds as Novel Potential Anticancer Agents |
title_short | Selenium Compounds as Novel Potential Anticancer Agents |
title_sort | selenium compounds as novel potential anticancer agents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864035/ https://www.ncbi.nlm.nih.gov/pubmed/33498364 http://dx.doi.org/10.3390/ijms22031009 |
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