Co-crystal structures of HIV TAR RNA bound to lab-evolved proteins show key roles for arginine relevant to the design of cyclic peptide TAR inhibitors

RNA-protein interfaces control key replication events during the HIV-1 life cycle. The viral trans-activator of transcription (Tat) protein uses an archetypal arginine-rich motif (ARM) to recruit the host positive transcription elongation factor b (pTEFb) complex onto the viral trans-activation resp...

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Detalles Bibliográficos
Autores principales: Chavali, Sai Shashank, Mali, Sachitanand M., Jenkins, Jermaine L., Fasan, Rudi, Wedekind, Joseph E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864049/
https://www.ncbi.nlm.nih.gov/pubmed/33051202
http://dx.doi.org/10.1074/jbc.RA120.015444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864049/
https://www.ncbi.nlm.nih.gov/pubmed/33051202
http://dx.doi.org/10.1074/jbc.RA120.015444

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