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Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis

Amyloid fibrils are polymeric structures originating from aggregation of misfolded proteins. In vivo, proteolysis may modulate amyloidogenesis and fibril stability. In light chain (AL) amyloidosis, fragmented light chains (LCs) are abundant components of amyloid deposits; however, site and timing of...

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Detalles Bibliográficos
Autores principales:	Lavatelli, Francesca, Mazzini, Giulia, Ricagno, Stefano, Iavarone, Federica, Rognoni, Paola, Milani, Paolo, Nuvolone, Mario, Swuec, Paolo, Caminito, Serena, Tasaki, Masayoshi, Chaves-Sanjuan, Antonio, Urbani, Andrea, Merlini, Giampaolo, Palladini, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864057/ https://www.ncbi.nlm.nih.gov/pubmed/32952127 http://dx.doi.org/10.1074/jbc.RA120.013461

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