Cargando…

Analysis of β-lactone formation by clinically observed carbapenemases informs on a novel antibiotic resistance mechanism

An important mechanism of resistance to β-lactam antibiotics is via their β-lactamase–catalyzed hydrolysis. Recent work has shown that, in addition to the established hydrolysis products, the reaction of the class D nucleophilic serine β-lactamases (SBLs) with carbapenems also produces β-lactones. W...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aertker, Kristina M.J., Chan, H.T. Henry, Lohans, Christopher T., Schofield, Christopher J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864059/ https://www.ncbi.nlm.nih.gov/pubmed/32963107 http://dx.doi.org/10.1074/jbc.RA120.014607

Ejemplares similares

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii
por: Liu, Tongri, et al.
Publicado: (2021)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Human UTY(KDM6C) Is a Male-specific N(ϵ)-Methyl Lysyl Demethylase
por: Walport, Louise J., et al.
Publicado: (2014)

Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6
por: Islam, Md. Saiful, et al.
Publicado: (2019)

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor
por: Tarhonskaya, Hanna, et al.
Publicado: (2015)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN
por: Day, Martin A., et al.
Publicado: (2021)

Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor
por: Lalić, Jasna, et al.
Publicado: (2016)

A heterodimeric glutathione S-transferase that stereospecifically breaks lignin's β(R)-aryl ether bond reveals the diversity of bacterial β-etherases
por: Kontur, Wayne S., et al.
Publicado: (2019)

A New Mechanism for β‐Lactamases: Class D Enzymes Degrade 1β‐Methyl Carbapenems through Lactone Formation
por: Lohans, Christopher T., et al.
Publicado: (2018)

Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin
por: Opelt, Marissa, et al.
Publicado: (2016)

Structure and function of Bs164 β-mannosidase from Bacteroides salyersiae the founding member of glycoside hydrolase family GH164
por: Armstrong, Zachary, et al.
Publicado: (2020)

Structural Basis of Stereospecificity in the Bacterial Enzymatic Cleavage of β-Aryl Ether Bonds in Lignin
por: Helmich, Kate E., et al.
Publicado: (2016)

Stereochemical Features of Glutathione-dependent Enzymes in the Sphingobium sp. Strain SYK-6 β-Aryl Etherase Pathway
por: Gall, Daniel L., et al.
Publicado: (2014)

The GH130 Family of Mannoside Phosphorylases Contains Glycoside Hydrolases That Target β-1,2-Mannosidic Linkages in Candida Mannan
por: Cuskin, Fiona, et al.
Publicado: (2015)

Three mammalian tropomyosin isoforms have different regulatory effects on nonmuscle myosin-2B and filamentous β-actin in vitro
por: Pathan-Chhatbar, Salma, et al.
Publicado: (2018)

Unraveling the subtleties of β-(1→3)-glucan phosphorylase specificity in the GH94, GH149, and GH161 glycoside hydrolase families
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2019)

Identification of Euglena gracilis β-1,3-glucan phosphorylase and establishment of a new glycoside hydrolase (GH) family GH149
por: Kuhaudomlarp, Sakonwan, et al.
Publicado: (2018)

Novosphingobium aromaticivorans uses a Nu-class glutathione S-transferase as a glutathione lyase in breaking the β-aryl ether bond of lignin
por: Kontur, Wayne S., et al.
Publicado: (2018)

Structure and kinetics of indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa: Decarboxylation is not essential for indole formation
por: Söderholm, Annika, et al.
Publicado: (2020)

Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes
por: Balty, Clémence, et al.
Publicado: (2021)

Cellulases Dig Deep: IN SITU OBSERVATION OF THE MESOSCOPIC STRUCTURAL DYNAMICS OF ENZYMATIC CELLULOSE DEGRADATION
por: Bubner, Patricia, et al.
Publicado: (2012)

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes
por: Soo, Valerie W. C., et al.
Publicado: (2016)

ATPase Mechanism of the 5′-3′ DNA Helicase, RecD2: EVIDENCE FOR A PRE-HYDROLYSIS CONFORMATION CHANGE
por: Toseland, Christopher P., et al.
Publicado: (2013)

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)
por: Yates, Christopher J., et al.
Publicado: (2014)

Nitroarachidonic Acid, a Novel Peroxidase Inhibitor of Prostaglandin Endoperoxide H Synthases 1 and 2
por: Trostchansky, Andrés, et al.
Publicado: (2011)

Histidyl-tRNA Synthetase Urzymes: CLASS I AND II AMINOACYL tRNA SYNTHETASE URZYMES HAVE COMPARABLE CATALYTIC ACTIVITIES FOR COGNATE AMINO ACID ACTIVATION
por: Li, Li, et al.
Publicado: (2011)

(19)F NMR Monitoring of Reversible Protein Post‐Translational Modifications: Class D β‐Lactamase Carbamylation and Inhibition
por: van Groesen, Emma, et al.
Publicado: (2019)

Galactomannan Catabolism Conferred by a Polysaccharide Utilization Locus of Bacteroides ovatus: ENZYME SYNERGY AND CRYSTAL STRUCTURE OF A β-MANNANASE
por: Bågenholm, Viktoria, et al.
Publicado: (2017)

Urinary l-erythro-β-hydroxyasparagine—a novel serine racemase inhibitor and substrate of the Zn(2+)-dependent d-serine dehydratase
por: Ito, Tomokazu, et al.
Publicado: (2021)

A surface-exposed GH26 β-mannanase from Bacteroides ovatus: Structure, role, and phylogenetic analysis of BoMan26B
por: Bågenholm, Viktoria, et al.
Publicado: (2019)

Regulation of Response Regulator Autophosphorylation through Interdomain Contacts
por: Barbieri, Christopher M., et al.
Publicado: (2010)

Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA)
por: Ahangar, Mohd Syed, et al.
Publicado: (2018)

Identifying Natural Substrates for Dipeptidyl Peptidases 8 and 9 Using Terminal Amine Isotopic Labeling of Substrates (TAILS) Reveals in Vivo Roles in Cellular Homeostasis and Energy Metabolism
por: Wilson, Claire H., et al.
Publicado: (2013)

Secreted heme peroxidase from Dictyostelium discoideum: Insights into catalysis, structure, and biological role
por: Nicolussi, Andrea, et al.
Publicado: (2018)

Roles of distal aspartate and arginine of B-class dye-decolorizing peroxidase in heterolytic hydrogen peroxide cleavage
por: Pfanzagl, Vera, et al.
Publicado: (2018)

Inhibition of Plasma Kallikrein by a Highly Specific Active Site Blocking Antibody
por: Kenniston, Jon A., et al.
Publicado: (2014)

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM
por: Drees, Steffen Lorenz, et al.
Publicado: (2016)

The Contribution of Non-catalytic Carbohydrate Binding Modules to the Activity of Lytic Polysaccharide Monooxygenases
por: Crouch, Lucy I., et al.
Publicado: (2016)

Investigating the reaction and substrate preference of indole-3-acetaldehyde dehydrogenase from the plant pathogen Pseudomonas syringae PtoDC3000
por: Zhang, Kaleena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ppj9g1qpms4sfnd5a5slgnsjcp