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Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor core. βarrs are known to act as adaptor proteins bindin...

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Detalles Bibliográficos
Autores principales:	Pakharukova, Natalia, Masoudi, Ali, Pani, Biswaranjan, Staus, Dean P., Lefkowitz, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864071/ https://www.ncbi.nlm.nih.gov/pubmed/32978252 http://dx.doi.org/10.1074/jbc.RA120.015400

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