Cargando…

Allosteric activation of proto-oncogene kinase Src by GPCR–beta-arrestin complexes

G protein–coupled receptors (GPCRs) initiate signaling cascades via G-proteins and beta-arrestins (βarr). βarr-dependent actions begin with recruitment of βarr to the phosphorylated receptor tail and are followed by engagement with the receptor core. βarrs are known to act as adaptor proteins bindin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pakharukova, Natalia, Masoudi, Ali, Pani, Biswaranjan, Staus, Dean P., Lefkowitz, Robert J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Signal Transduction
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864071/ https://www.ncbi.nlm.nih.gov/pubmed/32978252 http://dx.doi.org/10.1074/jbc.RA120.015400

Ejemplares similares

Mapping the Putative G Protein-coupled Receptor (GPCR) Docking Site on GPCR Kinase 2: INSIGHTS FROM INTACT CELL PHOSPHORYLATION AND RECRUITMENT ASSAYS
por: Beautrait, Alexandre, et al.
Publicado: (2014)

Arresting a Transient Receptor Potential (TRP) Channel: β-ARRESTIN 1 MEDIATES UBIQUITINATION AND FUNCTIONAL DOWN-REGULATION OF TRPV4
por: Shukla, Arun K., et al.
Publicado: (2010)

β-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation
por: Ahn, Seungkirl, et al.
Publicado: (2009)

G Protein–Coupled Receptor Kinase 2, With β-Arrestin 2, Impairs Insulin-Induced Akt/Endothelial Nitric Oxide Synthase Signaling in ob/ob Mouse Aorta
por: Taguchi, Kumiko, et al.
Publicado: (2012)

Temporal Profiling of Orexin Receptor-Arrestin-Ubiquitin Complexes Reveals Differences between Receptor Subtypes
por: Dalrymple, Matthew B., et al.
Publicado: (2011)

Independent β-Arrestin2 and G(q)/Protein Kinase Cζ Pathways for ERK Stimulated by Angiotensin Type 1A Receptors in Vascular Smooth Muscle Cells Converge on Transactivation of the Epidermal Growth Factor Receptor
por: Kim, Jihee, et al.
Publicado: (2009)

Syk and Src Family Kinases Regulate C-type Lectin Receptor 2 (CLEC-2)-mediated Clustering of Podoplanin and Platelet Adhesion to Lymphatic Endothelial Cells
por: Pollitt, Alice Y., et al.
Publicado: (2014)

Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4
por: Butcher, Adrian J., et al.
Publicado: (2014)

Targeted Elimination of G Proteins and Arrestins Defines Their Specific Contributions to Both Intensity and Duration of G Protein-coupled Receptor Signaling
por: Alvarez-Curto, Elisa, et al.
Publicado: (2016)

Functional and structural characterization of allosteric activation of phospholipase Cε by Rap1A
por: Sieng, Monita, et al.
Publicado: (2021)

The GPCR–β-arrestin complex allosterically activates C-Raf by binding its amino terminus
por: Zang, Yunxiang, et al.
Publicado: (2021)

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique G(i)-functional Bias
por: Bolognini, Daniele, et al.
Publicado: (2016)

Integrin-Associated Protein Association With Src Homology 2 Domain Containing Tyrosine Phosphatase Substrate 1 Regulates IGF-I Signaling In Vivo
por: Maile, Laura A., et al.
Publicado: (2008)

Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders
por: Babinsky, Valerie N., et al.
Publicado: (2016)

Phosphorylation of the Kinase Interaction Motif in Mitogen-activated Protein (MAP) Kinase Phosphatase-4 Mediates Cross-talk between Protein Kinase A and MAP Kinase Signaling Pathways
por: Dickinson, Robin J., et al.
Publicado: (2011)

Signaling to Extracellular Signal-regulated Kinase from ErbB1 Kinase and Protein Kinase C: FEEDBACK, HETEROGENEITY, AND GATING
por: Perrett, Rebecca M, et al.
Publicado: (2013)

Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3
por: Bassi, Rekha, et al.
Publicado: (2017)

Hyperglycemia Enhances IGF-I–Stimulated Src Activation via Increasing Nox4-Derived Reactive Oxygen Species in a PKCζ-Dependent Manner in Vascular Smooth Muscle Cells
por: Xi, Gang, et al.
Publicado: (2012)

Parkin Regulates the Activity of Pyruvate Kinase M2
por: Liu, Kun, et al.
Publicado: (2016)

Defining the Contribution of AMP-activated Protein Kinase (AMPK) and Protein Kinase C (PKC) in Regulation of Glucose Uptake by Metformin in Skeletal Muscle Cells
por: Turban, Sophie, et al.
Publicado: (2012)

Engineering A-kinase Anchoring Protein (AKAP)-selective Regulatory Subunits of Protein Kinase A (PKA) through Structure-based Phage Selection
por: Gold, Matthew G., et al.
Publicado: (2013)

Phosphorylation of protein kinase A (PKA) regulatory subunit RIα by protein kinase G (PKG) primes PKA for catalytic activity in cells
por: Haushalter, Kristofer J., et al.
Publicado: (2018)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Signal Integration and Coincidence Detection in the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Cascade: CONCOMITANT ACTIVATION OF RECEPTOR TYROSINE KINASES AND OF LRP-1 LEADS TO SUSTAINED ERK PHOSPHORYLATION VIA DOWN-REGULATION OF DUAL SPECIFICITY PHOSPHATASES (DUSP1 AND -6)
por: Geetha, Nishamol, et al.
Publicado: (2011)

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes
por: Tan, Shi-Xiong, et al.
Publicado: (2012)

MYPT1 Protein Isoforms Are Differentially Phosphorylated by Protein Kinase G
por: Yuen, Samantha, et al.
Publicado: (2011)

Direct and Indirect Control of Mitogen-activated Protein Kinase Pathway-associated Components, BRAP/IMP E3 Ubiquitin Ligase and CRAF/RAF1 Kinase, by the Deubiquitylating Enzyme USP15
por: Hayes, Sebastian D., et al.
Publicado: (2012)

MAPKKK-independent Regulation of the Hog1 Stress-activated Protein Kinase in Candida albicans
por: Cheetham, Jill, et al.
Publicado: (2011)

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen
por: Gilio, Karen, et al.
Publicado: (2010)

Cyclic GMP Kinase I Modulates Glucagon Release From Pancreatic α-Cells
por: Leiss, Veronika, et al.
Publicado: (2011)

Negative Regulation of TGFβ Signaling by the Kinase LKB1 and the Scaffolding Protein LIP1
por: Morén, Anita, et al.
Publicado: (2011)

Class II Phosphoinositide 3-Kinase Regulates Exocytosis of Insulin Granules in Pancreatic β Cells
por: Dominguez, Veronica, et al.
Publicado: (2011)

Protein Kinase PKN1 Represses Wnt/β-Catenin Signaling in Human Melanoma Cells
por: James, Richard G., et al.
Publicado: (2013)

Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through β-catenin
por: Mishra, Jayshree, et al.
Publicado: (2017)

A ubiquitin-like domain controls protein kinase D dimerization and activation by trans-autophosphorylation
por: Elsner, Daniel J., et al.
Publicado: (2019)

Dual Regulation of Glycogen Synthase Kinase 3 (GSK3)α/β by Protein Kinase C (PKC)α and Akt Promotes Thrombin-mediated Integrin α(IIb)β(3) Activation and Granule Secretion in Platelets
por: Moore, Samantha F., et al.
Publicado: (2013)

Structural Mechanism for the Specific Assembly and Activation of the Extracellular Signal Regulated Kinase 5 (ERK5) Module
por: Glatz, Gábor, et al.
Publicado: (2013)

G Protein-coupled Receptor Kinases Phosphorylate LRP6 in the Wnt Pathway
por: Chen, Minyong, et al.
Publicado: (2009)

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2
por: Suvasini, Ramaswamy, et al.
Publicado: (2011)

Nucleo-cytosolic Shuttling of FoxO1 Directly Regulates Mouse Ins2 but Not Ins1 Gene Expression in Pancreatic Beta Cells (MIN6)
por: Meur, Gargi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_li384oanofb0el7qp2m2oj88v5