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Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology
The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864073/ https://www.ncbi.nlm.nih.gov/pubmed/33020183 http://dx.doi.org/10.1074/jbc.REV120.014391 |
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author | Chen, Carolyn G. Iozzo, Renato V. |
author_facet | Chen, Carolyn G. Iozzo, Renato V. |
author_sort | Chen, Carolyn G. |
collection | PubMed |
description | The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coordinated. Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and angiogenesis. Specifically, we assess the role of proteoglycan-evoked autophagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner. We discuss extracellular hyaluronan biology and the post-transcriptional and post-translational modifications that regulate its main synthesizer, HAS2. We highlight the emerging group of proteoglycans that utilize outside-in signaling to modulate autophagy and angiogenesis in cancer microenvironments and thoroughly review the most up-to-date understanding of endorepellin signaling in vascular endothelia, providing insight into the temporal complexities involved. |
format | Online Article Text |
id | pubmed-7864073 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-78640732021-06-10 Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology Chen, Carolyn G. Iozzo, Renato V. J Biol Chem JBC Reviews The extracellular matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological functions. A prominent body of work posits matrix constituents as master regulators of autophagy and angiogenesis and provides molecular insight into how these two processes are coordinated. Here, we review current understanding of the molecular mechanisms underlying hyaluronan and HAS2 regulation and the role of soluble proteoglycan in affecting autophagy and angiogenesis. Specifically, we assess the role of proteoglycan-evoked autophagy in regulating angiogenesis via the HAS2-hyaluronan axis and ATG9A, a novel HAS2 binding partner. We discuss extracellular hyaluronan biology and the post-transcriptional and post-translational modifications that regulate its main synthesizer, HAS2. We highlight the emerging group of proteoglycans that utilize outside-in signaling to modulate autophagy and angiogenesis in cancer microenvironments and thoroughly review the most up-to-date understanding of endorepellin signaling in vascular endothelia, providing insight into the temporal complexities involved. American Society for Biochemistry and Molecular Biology 2021-01-13 /pmc/articles/PMC7864073/ /pubmed/33020183 http://dx.doi.org/10.1074/jbc.REV120.014391 Text en © 2020 © 2020 Chen and Iozzo. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | JBC Reviews Chen, Carolyn G. Iozzo, Renato V. Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title | Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title_full | Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title_fullStr | Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title_full_unstemmed | Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title_short | Angiostatic cues from the matrix: Endothelial cell autophagy meets hyaluronan biology |
title_sort | angiostatic cues from the matrix: endothelial cell autophagy meets hyaluronan biology |
topic | JBC Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864073/ https://www.ncbi.nlm.nih.gov/pubmed/33020183 http://dx.doi.org/10.1074/jbc.REV120.014391 |
work_keys_str_mv | AT chencarolyng angiostaticcuesfromthematrixendothelialcellautophagymeetshyaluronanbiology AT iozzorenatov angiostaticcuesfromthematrixendothelialcellautophagymeetshyaluronanbiology |