Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling

Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: G(s), G(i/o), G(q/11), and G(12/13). Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncog...

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Detalles Bibliográficos
Autores principales: Maziarz, Marcin, Federico, Anthony, Zhao, Jingyi, Dujmusic, Lorena, Zhao, Zhiming, Monti, Stefano, Varelas, Xaralabos, Garcia-Marcos, Mikel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864081/
https://www.ncbi.nlm.nih.gov/pubmed/33109615
http://dx.doi.org/10.1074/jbc.AC120.014698

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864081/
https://www.ncbi.nlm.nih.gov/pubmed/33109615
http://dx.doi.org/10.1074/jbc.AC120.014698

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