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Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling
Heterotrimeric G-proteins are signaling switches broadly divided into four families based on the sequence and functional similarity of their Gα subunits: G(s), G(i/o), G(q/11), and G(12/13). Artificial mutations that activate Gα subunits of each of these families have long been known to induce oncog...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864081/ https://www.ncbi.nlm.nih.gov/pubmed/33109615 http://dx.doi.org/10.1074/jbc.AC120.014698 |