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Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression

The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid...

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Autores principales: Makalish, Tatyana P., Golovkin, Ilya O., Oberemok, Volodymyr V., Laikova, Kateryna V., Temirova, Zenure Z., Serdyukova, Olesya A., Novikov, Ilya A., Rosovskyi, Roman A., Gordienko, Andrey I., Zyablitskaya, Evgeniya Yu., Gafarova, Elvina A., Yurchenko, Kseniya A., Fomochkina, Iryna I., Kubyshkin, Anatoly V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864158/
https://www.ncbi.nlm.nih.gov/pubmed/33498456
http://dx.doi.org/10.3390/ijms22031022
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author Makalish, Tatyana P.
Golovkin, Ilya O.
Oberemok, Volodymyr V.
Laikova, Kateryna V.
Temirova, Zenure Z.
Serdyukova, Olesya A.
Novikov, Ilya A.
Rosovskyi, Roman A.
Gordienko, Andrey I.
Zyablitskaya, Evgeniya Yu.
Gafarova, Elvina A.
Yurchenko, Kseniya A.
Fomochkina, Iryna I.
Kubyshkin, Anatoly V.
author_facet Makalish, Tatyana P.
Golovkin, Ilya O.
Oberemok, Volodymyr V.
Laikova, Kateryna V.
Temirova, Zenure Z.
Serdyukova, Olesya A.
Novikov, Ilya A.
Rosovskyi, Roman A.
Gordienko, Andrey I.
Zyablitskaya, Evgeniya Yu.
Gafarova, Elvina A.
Yurchenko, Kseniya A.
Fomochkina, Iryna I.
Kubyshkin, Anatoly V.
author_sort Makalish, Tatyana P.
collection PubMed
description The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira(®)); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease.
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spelling pubmed-78641582021-02-06 Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression Makalish, Tatyana P. Golovkin, Ilya O. Oberemok, Volodymyr V. Laikova, Kateryna V. Temirova, Zenure Z. Serdyukova, Olesya A. Novikov, Ilya A. Rosovskyi, Roman A. Gordienko, Andrey I. Zyablitskaya, Evgeniya Yu. Gafarova, Elvina A. Yurchenko, Kseniya A. Fomochkina, Iryna I. Kubyshkin, Anatoly V. Int J Mol Sci Article The urgency of the search for inexpensive and effective drugs with localized action for the treatment of rheumatoid arthritis continues unabated. In this study, for the first time we investigated the Cytos-11 antisense oligonucleotide suppression of TNF-α gene expression in a rat model of rheumatoid arthritis induced by complete Freund’s adjuvant. Cytos-11 has been shown to effectively reduce peripheral blood concentrations of TNF-α, reduce joint inflammation, and reduce pannus development. The results achieved following treatment with the antisense oligonucleotide Cytos-11 were similar to those of adalimumab (Humira(®)); they also compared favorably with those results, which provides evidence of the promise of drugs based on antisense technologies in the treatment of this disease. MDPI 2021-01-20 /pmc/articles/PMC7864158/ /pubmed/33498456 http://dx.doi.org/10.3390/ijms22031022 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Makalish, Tatyana P.
Golovkin, Ilya O.
Oberemok, Volodymyr V.
Laikova, Kateryna V.
Temirova, Zenure Z.
Serdyukova, Olesya A.
Novikov, Ilya A.
Rosovskyi, Roman A.
Gordienko, Andrey I.
Zyablitskaya, Evgeniya Yu.
Gafarova, Elvina A.
Yurchenko, Kseniya A.
Fomochkina, Iryna I.
Kubyshkin, Anatoly V.
Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title_full Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title_fullStr Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title_full_unstemmed Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title_short Anti-Rheumatic Effect of Antisense Oligonucleotide Cytos-11 Targeting TNF-α Expression
title_sort anti-rheumatic effect of antisense oligonucleotide cytos-11 targeting tnf-α expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864158/
https://www.ncbi.nlm.nih.gov/pubmed/33498456
http://dx.doi.org/10.3390/ijms22031022
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