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Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips

This study aimed to develop an automated optical inspection (AOI) system that can rapidly and precisely measure the dimensions of microchannels embedded inside a transparent polymeric substrate, and can eventually be used on the production line of a factory. The AOI system is constructed based on Sn...

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Autores principales: Chen, Pin-Chuan, Lin, Ya-Ting, Truong, Chi-Minh, Chen, Pai-Shan, Chiang, Huihua-Kenny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864200/
https://www.ncbi.nlm.nih.gov/pubmed/33498437
http://dx.doi.org/10.3390/s21030698
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author Chen, Pin-Chuan
Lin, Ya-Ting
Truong, Chi-Minh
Chen, Pai-Shan
Chiang, Huihua-Kenny
author_facet Chen, Pin-Chuan
Lin, Ya-Ting
Truong, Chi-Minh
Chen, Pai-Shan
Chiang, Huihua-Kenny
author_sort Chen, Pin-Chuan
collection PubMed
description This study aimed to develop an automated optical inspection (AOI) system that can rapidly and precisely measure the dimensions of microchannels embedded inside a transparent polymeric substrate, and can eventually be used on the production line of a factory. The AOI system is constructed based on Snell’s law. The concept holds that, when light travels through two transparent media (air and the microfluidic chip transparent material), by capturing the parallel refracted light from a light source that went through the microchannel using a camera with a telecentric lens, the image can be analyzed using formulas derived from Snell’s law to measure the dimensions of the microchannel cross-section. Through the NI LabVIEW 2018 SP1 programming interface, we programmed this system to automatically analyze the captured image and acquire all the needed data. The system then processes these data using custom-developed formulas to calculate the height and width measurements of the microchannel cross-sections and presents the results on the human–machine interface (HMI). In this study, a single and straight microchannel with a cross-sectional area of 300 μm × 300 μm and length of 44 mm was micromachined and sealed with another polymeric substrate by a solvent bonding method for experimentations. With this system, 45 cross-sectional areas along the straight microchannel were measured within 20 s, and experiment results showed that the average measured error was less than 2%.
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spelling pubmed-78642002021-02-06 Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips Chen, Pin-Chuan Lin, Ya-Ting Truong, Chi-Minh Chen, Pai-Shan Chiang, Huihua-Kenny Sensors (Basel) Letter This study aimed to develop an automated optical inspection (AOI) system that can rapidly and precisely measure the dimensions of microchannels embedded inside a transparent polymeric substrate, and can eventually be used on the production line of a factory. The AOI system is constructed based on Snell’s law. The concept holds that, when light travels through two transparent media (air and the microfluidic chip transparent material), by capturing the parallel refracted light from a light source that went through the microchannel using a camera with a telecentric lens, the image can be analyzed using formulas derived from Snell’s law to measure the dimensions of the microchannel cross-section. Through the NI LabVIEW 2018 SP1 programming interface, we programmed this system to automatically analyze the captured image and acquire all the needed data. The system then processes these data using custom-developed formulas to calculate the height and width measurements of the microchannel cross-sections and presents the results on the human–machine interface (HMI). In this study, a single and straight microchannel with a cross-sectional area of 300 μm × 300 μm and length of 44 mm was micromachined and sealed with another polymeric substrate by a solvent bonding method for experimentations. With this system, 45 cross-sectional areas along the straight microchannel were measured within 20 s, and experiment results showed that the average measured error was less than 2%. MDPI 2021-01-20 /pmc/articles/PMC7864200/ /pubmed/33498437 http://dx.doi.org/10.3390/s21030698 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Letter
Chen, Pin-Chuan
Lin, Ya-Ting
Truong, Chi-Minh
Chen, Pai-Shan
Chiang, Huihua-Kenny
Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title_full Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title_fullStr Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title_full_unstemmed Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title_short Development of an Automated Optical Inspection System for Rapidly and Precisely Measuring Dimensions of Embedded Microchannel Structures in Transparent Bonded Chips
title_sort development of an automated optical inspection system for rapidly and precisely measuring dimensions of embedded microchannel structures in transparent bonded chips
topic Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864200/
https://www.ncbi.nlm.nih.gov/pubmed/33498437
http://dx.doi.org/10.3390/s21030698
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