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IP(3)-mediated Ca(2+) release regulates atrial Ca(2+) transients and pacemaker function by stimulation of adenylyl cyclases

Inositol trisphosphate (IP(3)) is a Ca(2+)-mobilizing second messenger shown to modulate atrial muscle contraction and is thought to contribute to atrial fibrillation. Cellular pathways underlying IP(3) actions in cardiac tissue remain poorly understood, and the work presented here addresses the que...

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Detalles Bibliográficos
Autores principales:	Capel, Rebecca A., Bose, Samuel J., Collins, Thomas P., Rajasundaram, Skanda, Ayagama, Thamali, Zaccolo, Manuela, Burton, Rebecca-Ann Beatrice, Terrar, Derek A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Physiological Society 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864251/ https://www.ncbi.nlm.nih.gov/pubmed/33064562 http://dx.doi.org/10.1152/ajpheart.00380.2020

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