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The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients

According to recent data, psoriatic patients have an increased prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, compared with the general population. In some published studies, the severity and presence of psoriasis disease were correlated with the severity of NAFLD. I...

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Autores principales: Neagoe, Carmen-Daniela, Farmazon, Anca-Smaranda, Amzolini, Anca-Maria, Singer, Cristina-Elena, Ianoşi, Simona-Laura, Tutunaru, Cristina-Violeta, Genunche-Dumitrescu, Amelia-Valentina, Ianoşi, Nicolae-Gabriel, Păun, Ion, Leru, Polliana-Mihaela, Tica, Oana-Sorina, Popescu, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864297/
https://www.ncbi.nlm.nih.gov/pubmed/33544802
http://dx.doi.org/10.47162/RJME.61.2.20
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author Neagoe, Carmen-Daniela
Farmazon, Anca-Smaranda
Amzolini, Anca-Maria
Singer, Cristina-Elena
Ianoşi, Simona-Laura
Tutunaru, Cristina-Violeta
Genunche-Dumitrescu, Amelia-Valentina
Ianoşi, Nicolae-Gabriel
Păun, Ion
Leru, Polliana-Mihaela
Tica, Oana-Sorina
Popescu, Mihaela
author_facet Neagoe, Carmen-Daniela
Farmazon, Anca-Smaranda
Amzolini, Anca-Maria
Singer, Cristina-Elena
Ianoşi, Simona-Laura
Tutunaru, Cristina-Violeta
Genunche-Dumitrescu, Amelia-Valentina
Ianoşi, Nicolae-Gabriel
Păun, Ion
Leru, Polliana-Mihaela
Tica, Oana-Sorina
Popescu, Mihaela
author_sort Neagoe, Carmen-Daniela
collection PubMed
description According to recent data, psoriatic patients have an increased prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, compared with the general population. In some published studies, the severity and presence of psoriasis disease were correlated with the severity of NAFLD. In the current study, we aimed to compare the sensibility and specificity of the non-invasive scores and liver biopsy in determining fibrosis in patients with NAFLD and moderate to severe psoriasis. We performed the scientific research from June 2014–December 2017 and we included 71 patients: 40 patients with NAFLD and 31 patients with moderate to severe psoriasis according to Psoriasis Area and Severity Index (PASI) score and NAFLD, who received Etanercept treatment for at least one year. Based on the clinical and laboratory data, we calculated the following scores for fibrosis: body mass index (BMI), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, diabetes (BARD) score, Fibrosis-4 (FIB-4) score, and NAFLD fibrosis score (NFS). For liver biopsy, we used the Menghini technique. By calculating Kendall’s test, we also observed a strong direct correlation between the degree of fibrosis and FIB-4 (tau=0.558) and NFS (tau=0.490) scores, with a critical statistical impact, and the lack of a correlation with the BARD score (tau=0.095; p=0.332). The hepatic biopsy allowed the more accurate establishment of the role of the non-invasive tests in the diagnosis of the lesions of steatosis, steatohepatitis, and hepatic fibrosis. The non-invasive tests are most useful for the exclusion of the evolution lesions and for the confirmation of the advanced stages of the disease. Among these, the NFS score proved a high statistically significant correlation (p<0.0001) with the fibrosis histological lesions.
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spelling pubmed-78642972021-02-08 The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients Neagoe, Carmen-Daniela Farmazon, Anca-Smaranda Amzolini, Anca-Maria Singer, Cristina-Elena Ianoşi, Simona-Laura Tutunaru, Cristina-Violeta Genunche-Dumitrescu, Amelia-Valentina Ianoşi, Nicolae-Gabriel Păun, Ion Leru, Polliana-Mihaela Tica, Oana-Sorina Popescu, Mihaela Rom J Morphol Embryol Original Paper According to recent data, psoriatic patients have an increased prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, compared with the general population. In some published studies, the severity and presence of psoriasis disease were correlated with the severity of NAFLD. In the current study, we aimed to compare the sensibility and specificity of the non-invasive scores and liver biopsy in determining fibrosis in patients with NAFLD and moderate to severe psoriasis. We performed the scientific research from June 2014–December 2017 and we included 71 patients: 40 patients with NAFLD and 31 patients with moderate to severe psoriasis according to Psoriasis Area and Severity Index (PASI) score and NAFLD, who received Etanercept treatment for at least one year. Based on the clinical and laboratory data, we calculated the following scores for fibrosis: body mass index (BMI), aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio, diabetes (BARD) score, Fibrosis-4 (FIB-4) score, and NAFLD fibrosis score (NFS). For liver biopsy, we used the Menghini technique. By calculating Kendall’s test, we also observed a strong direct correlation between the degree of fibrosis and FIB-4 (tau=0.558) and NFS (tau=0.490) scores, with a critical statistical impact, and the lack of a correlation with the BARD score (tau=0.095; p=0.332). The hepatic biopsy allowed the more accurate establishment of the role of the non-invasive tests in the diagnosis of the lesions of steatosis, steatohepatitis, and hepatic fibrosis. The non-invasive tests are most useful for the exclusion of the evolution lesions and for the confirmation of the advanced stages of the disease. Among these, the NFS score proved a high statistically significant correlation (p<0.0001) with the fibrosis histological lesions. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-09-17 /pmc/articles/PMC7864297/ /pubmed/33544802 http://dx.doi.org/10.47162/RJME.61.2.20 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
Neagoe, Carmen-Daniela
Farmazon, Anca-Smaranda
Amzolini, Anca-Maria
Singer, Cristina-Elena
Ianoşi, Simona-Laura
Tutunaru, Cristina-Violeta
Genunche-Dumitrescu, Amelia-Valentina
Ianoşi, Nicolae-Gabriel
Păun, Ion
Leru, Polliana-Mihaela
Tica, Oana-Sorina
Popescu, Mihaela
The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title_full The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title_fullStr The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title_full_unstemmed The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title_short The role of non-invasive scores in determining the liver fibrosis in NAFLD and psoriatic patients
title_sort role of non-invasive scores in determining the liver fibrosis in nafld and psoriatic patients
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864297/
https://www.ncbi.nlm.nih.gov/pubmed/33544802
http://dx.doi.org/10.47162/RJME.61.2.20
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