Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment

Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome corona...

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Autores principales: Biţă, Andrei, Scorei, Ion Romulus, Mogoantă, Laurenţiu, Bejenaru, Cornelia, Mogoşanu, George Dan, Bejenaru, Ludovic Everard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864303/
https://www.ncbi.nlm.nih.gov/pubmed/33544784
http://dx.doi.org/10.47162/RJME.61.2.02
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author Biţă, Andrei
Scorei, Ion Romulus
Mogoantă, Laurenţiu
Bejenaru, Cornelia
Mogoşanu, George Dan
Bejenaru, Ludovic Everard
author_facet Biţă, Andrei
Scorei, Ion Romulus
Mogoantă, Laurenţiu
Bejenaru, Cornelia
Mogoşanu, George Dan
Bejenaru, Ludovic Everard
author_sort Biţă, Andrei
collection PubMed
description Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This review emphasizes the role of natural and semisynthetic candidate molecules for coronavirus disease 2019 (COVID-19) prophylaxis and treatment. The experimental evidence suggests that nature could offer huge possibilities for treatment of the COVID-19 pandemic.
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spelling pubmed-78643032021-02-08 Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment Biţă, Andrei Scorei, Ion Romulus Mogoantă, Laurenţiu Bejenaru, Cornelia Mogoşanu, George Dan Bejenaru, Ludovic Everard Rom J Morphol Embryol Review Coronaviruses (CoVs) represent a family of viruses that have numerous animal hosts, and they cause severe respiratory, as well as systemic and enteric infections, in humans. Currently, there are limited antiviral strategies for treating patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The lack of specific antiviral medicines and SARS-CoV-2 vaccines continues to aggravate the situation. Natural product-based antiviral drugs have been used in the two previous CoV outbreaks: Middle East respiratory syndrome coronavirus (MERS-CoV) and the first SARS-CoV. This review emphasizes the role of natural and semisynthetic candidate molecules for coronavirus disease 2019 (COVID-19) prophylaxis and treatment. The experimental evidence suggests that nature could offer huge possibilities for treatment of the COVID-19 pandemic. Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest 2020 2020-09-25 /pmc/articles/PMC7864303/ /pubmed/33544784 http://dx.doi.org/10.47162/RJME.61.2.02 Text en Copyright © 2020, Academy of Medical Sciences, Romanian Academy Publishing House, Bucharest http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Review
Biţă, Andrei
Scorei, Ion Romulus
Mogoantă, Laurenţiu
Bejenaru, Cornelia
Mogoşanu, George Dan
Bejenaru, Ludovic Everard
Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title_full Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title_fullStr Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title_full_unstemmed Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title_short Natural and semisynthetic candidate molecules for COVID-19 prophylaxis and treatment
title_sort natural and semisynthetic candidate molecules for covid-19 prophylaxis and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864303/
https://www.ncbi.nlm.nih.gov/pubmed/33544784
http://dx.doi.org/10.47162/RJME.61.2.02
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